Aspirin for primary prevention of cardiovascular events: meta-analysis of randomized controlled trials and subgroup analysis by sex and diabetes status.

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Xie, Manling; Shan, Zhilei; Zhang, Yan; Chen, Sijing; Yang, Wei; Bao, Wei; Rong, Ying; Yu, Xuefeng; Hu, Frank B.; Liu, Liegang;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 9, issue 10 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0090286., doi: 10.1371/journal.pone.0090286, pmc: PMC4215843
  • Subject: Cardiovascular Diseases in Women | Vascular Medicine | Research Article | Mathematics | Research Design | Myocardial Infarction | Diabetes Mellitus | Clinical Medicine | Physical Sciences | Public and Occupational Health | Pharmacology | Research Assessment | Global Health | Metabolic Disorders | Statistics (Mathematics) | Adverse Reactions | Clinical Research Design | Research and Analysis Methods | Meta-Analysis | Medicine | Cardiovascular Diseases | Stroke | Cardiology | Q | R | Type 2 Diabetes | Science | Clinical Pharmacology | Medicine and Health Sciences | Systematic Reviews | Diabetic Endocrinology | Statistical Methods | Endocrinology

Objective: To evaluate the benefits and harms of aspirin for the primary prevention of CVD and determine whether the effects vary by sex and diabetes status. Methods: We searched Medline, Embase, and Cochrane databases for randomized controlled trials comparing the effe... View more
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