Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

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Perry, John RB; Day, Felix; Elks, Cathy E; Sulem, Patrick; Thompson, Deborah J; Ferreira, Teresa; He, Chunyan; Chasman, Daniel I; Esko, Toenu; Thorleifsson, Gudmar; Albrecht, Eva; Ang, Wei Q; Corre, Tanguy; Cousminer, Diana L; Feenstra, Bjarke; Franceschini, Nora; Ganna, Andrea; Johnson, Andrew D; Kjellqvist, Sanela; Lunetta, Kathryn L; McMahon, George; Nolte, Ilja M; Paternoster, Lavinia; Porcu, Eleonora; Smith, Albert V; Stolk, Lisette; Teumer, Alexander; Tsernikova, Natalia; Tikkanen, Emmi; Ulivi, Sheila; ... view all 198 authors
  • Publisher: Nature Research
  • Journal: volume 514, issue 7,520, pages 92-7issn: 0028-0836, eissn: 1476-4687
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1038/nature13545, doi: 10.1038/nature13545., pmc: PMC4185210
  • Subject: METAANALYSIS | DISEASE | CENTRAL PRECOCIOUS PUBERTY | REVEALS | Multidisciplinary Sciences | GENE-EXPRESSION | WIDE ASSOCIATION | VARIANTS | Science & Technology | Science & Technology - Other Topics | Article | BREAST-CANCER RISK | CELLS | Adolescent; Age Factors; Alleles; Body Mass Index; Breast Neoplasms/genetics; Cardiovascular Diseases/genetics; Child; Diabetes Mellitus, Type 2/genetics; Europe/ethnology; Female; Genetic Loci/genetics; Genome-Wide Association Study; Genomic Imprinting/genetics; Humans; Hypothalamo-Hypophyseal System/physiology; Intercellular Signaling Peptides and Proteins/genetics; Male; Membrane Proteins/genetics; Menarche/genetics; Obesity/genetics; Ovary/physiology; Parents; Polymorphism, Single Nucleotide/genetics; Potassium Channels, Tandem Pore Domain/genetics; Proteins/genetics; Quantitative Trait Loci/genetics; Receptors, GABA-B/metabolism; Receptors, Retinoic Acid/metabolism; Ribonucleoproteins/genetics | HUMAN PREFRONTAL CORTEX

Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disord... View more
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