Quantification of rifampicin in human plasma and cerebrospinal fluid by a highly sensitive and rapid liquid chromatographic–tandem mass spectrometric method

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Srivastava, Abhishek; Waterhouse, David; Ardrey, Alison; Ward, Stephen A.;
(2012)
  • Publisher: Elsevier BV
  • Journal: Journal of Pharmaceutical and Biomedical Analysis,volume 70,issue 6,pages523-528 (issn: 0731-7085, eissn: 1873-264X)
  • Related identifiers: doi: 10.1016/j.jpba.2012.05.028, pmc: PMC3458211
  • Subject: RIF, rifampicin | Rifampicin | Pharmaceutical Science | TB, tuberculosis | Quantitative assay | Analytical Chemistry | Article | LC–MS/MS | CSF, cerebrospinal fluid | Drug Discovery | Spectroscopy | Cerebrospinal fluid | MTB, mycobacterium tuberculosis | RPT, rifapentine | Clinical Biochemistry | Human plasma | Validation

A highly sensitive and rapid liquid chromatography tandem mass spectrometry (LC–MS/MS) method has been developed to measure the levels of the antitubercular drug rifampicin (RIF) in human plasma and cerebrospinal fluid (CSF). The analyte and internal standard (IS) were ... View more
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