A“Proteoglycan Targeting Strategy” for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model

Article English OPEN
Peyrode, Caroline; Gouin, François; Vidal, Aurélien; Auzeloux, Philippe; Besse, Sophie; Dauplat, Marie-Mélanie; Askienazy, Serge; Heymann, Dominique; Chezal, Jean-Michel; Redini, Françoise; Miot-Noirault, Elisabeth; (2011)
  • Publisher: Hindawi Publishing Corporation
  • Journal: Sarcoma,volume 2,011 (issn: 1357-714X, eissn: 1369-1643)
  • Related identifiers: pmc: PMC3038667, doi: 10.1155/2011/691608
  • Subject: Research Article | RC254-282 | Article Subject | Neoplasms. Tumors. Oncology. Including cancer and carcinogens
    mesheuropmc: viruses

Our lab developed 99mTc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint. This paper reports preclinical results of 99mTc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC). 99mTc-NTP 15-5 imaging of SRC... View more
  • References (35)
    35 references, page 1 of 4

    Madelmont, J. C., Giraud, I., Nicolas, C.. inventors. Cyclopharma Laboratoires, assignee. Novel quaternary ammonium derivatives, method for preparing same and pharmaceutical use.

    Nicolas, C., Borel, M., Maurizis, J. C., Gallais, N., Rapp, M., Ollier, M., Verny, M., Madelmont, J. C.. Synthesis of N-quaternary ammonium [3H] and [99mTc]Polyazamacrocycles, potential radiotracers for cartilage imaging. Journal of Labelled Compounds and Radiopharmaceuticals. 2000; 43 (6): 585-594

    Maurizis, J. C., Rapp, M., Nicolas, C., Ollier, M., Verny, M., Madelmont, J. C.. Disposition in rats of N-pyridinium-propyl-cyclam, N- triethylammoniumpropyl-cyclam, and N-[triethylammonium]-3-propyl-[15]ane-N5, potential cartilage imaging agents. Drug Metabolism and Disposition. 2000; 28 (4): 418-422

    Ollier, M., Maurizis, J. C., Nicolas, C., Bonafous, J., De Latour, M., Veyre, A., Madelmont, J. C.. Joint scintigraphy in rabbits with 99mTc-N-[3-(triethylammonio)propyl]-15ane-N5, a new radiodiagnostic agent for articular cartilage imaging. Journal of Nuclear Medicine. 2001; 42 (1): 141-145

    Miot-Noirault, E., Vidal, A., Pastoureau, P., Bonafous, J., Chomel, A., Sarry, L., Audin, L., Madelmont, J.-C., Moins, N.. Early detection and monitoring of cartilage alteration in the experimental meniscectomised guinea pig model of osteoarthritis by 99mTc-NTP 15-5 scintigraphy. European Journal of Nuclear Medicine and Molecular Imaging. 2007; 34 (8): 1280-1290

    Miot-Noirault, E., Vidal, A., Auzeloux, P., Madelmont, J. C., Maublant, J., Moins, N.. First in vivo SPECT imaging of mouse femorotibial cartilage using 99mTc-NTP 15-5. Molecular Imaging. 2008; 7 (6): 263-271

    Lamoureux, F., Baud'huin, M., Duplomb, L., Heymann, D., Rédini, F.. Proteoglycans: key partners in bone cell biology. BioEssays. 2007; 29 (8): 758-771

    World Health Organization, null, Fletcher, C. D. M., Unni, K. K., Mertens, F.. Cartilage tumours. World Health Organization Classification of Tumours: Pathology and Genetics, Tumours of Soft Tissue and Bone. 2002: 234-257

    Gelderblom, H., Hogendoorn, P. C. W., Dijkstra, S. D., Van Rijswijk, C. S., Krol, A. D., Taminiau, A. H. M., Bovée, J. V. M. G.. The clinical approach towards chondrosarcoma. Oncologist. 2008; 13 (3): 320-329

    Chow, W. A.. Update on chondrosarcomas. Current Opinion in Oncology. 2007; 19 (4): 371-376

  • Similar Research Results (4)
  • Metrics
    No metrics available
Share - Bookmark