A Vanillin Derivative Causes Mitochondrial Dysfunction and Triggers Oxidative Stress in Cryptococcus neoformans

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Jin Hyo Kim; Han-Ok Lee; Yong-Joon Cho; Jeongmi Kim; Jongsik Chun; Jaehyuk Choi; Younghoon Lee; Won Hee Jung;
(2014)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 9, issue 2 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0089122, pmc: PMC3930674
  • Subject: Chemistry | Microbial Pathogens | Research Article | Biology | Cryptococcal Meningitis | Infectious Diseases | Microbiology | Medicine | Functional Genomics | Cryptococcosis | Q | Pathogenesis | R | Infectious Diseases of the Nervous System | Science | Genomics | Fungal Diseases | Mycology | Medicinal Chemistry | Neurology

Vanillin is a well-known food and cosmetic additive and has antioxidant and antimutagenic properties. It has also been suggested to have antifungal activity against major human pathogenic fungi, although it is not very effective. In this study, the antifungal activities... View more
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