Therapeutic target discovery using Boolean network attractors: avoiding pathological phenotypes

Article, Preprint English OPEN
Poret, Arnaud; Boissel, Jean-Pierre;
(2014)
  • Publisher: Elsevier Masson
  • Related identifiers: doi: 10.1016/j.crvi.2014.10.002
  • Subject: Fanconi anemia | [ SDV.BIBS ] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] | target identification | in silico | [ SDV.BBM.MN ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN] | biological networks | Boolean networks | [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] | drug discovery | [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN] | Quantitative Biology - Quantitative Methods | Quantitative Biology - Molecular Networks | therapeutic targets
    mesheuropmc: humanities

Since the publication of this article and among the possible improvements mentioned in the Conclusion, two improvements have been done: extending the algorithm for multivalued logic and considering the basins of attraction of the pathological attractors for selecting th... View more
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