High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers.

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Martin, Heather L.; Adams, Matthew; Higgins, Julie; Bond, Jacquelyn; Morrison, Ewan E.; Bell, Sandra M.; Warriner, Stuart; Nelson, Adam; Tomlinson, Darren C.;
(2014)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 9, issue 2 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.1371/journal.pone.0088338, pmc: PMC3914966
  • Subject: Signaling in Cellular Processes | Toxicology | Chemistry | Biotechnology | Cellular Stress Responses | Research Article | Biology | Molecular Cell Biology | Cell Death | Signal Transduction | Cell Growth | Medicine | Q | R | Chemical Biology | Science | Small Molecules

Toxicity is a major cause of failure in drug discovery and development, and whilst robust toxicological testing occurs, efficiency could be improved if compounds with cytotoxic characteristics were identified during primary compound screening. The use of high-content im... View more
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