Evaluation of approaches to monitor Staphylococcus aureus virulence factor expression during human disease

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Rozemeijer, Wouter; Fink, Pamela; Rojas, Eduardo; Jones, C. Hal; Pavliakova, Danka; Giardina, Peter; Murphy, Ellen; Liberator, Paul; Jiang, Qin; Girgenti, Douglas; Peters, Remco P. H.; Savelkoul, Paul H. M.; Jansen, Kathrin U.; Anderson, Annaliesa S.; Kluytmans, Jan;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 10,issue 2 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0116945, pmc: PMC4342157
  • Subject: Bacterial Capsules | Research Article | Staphylococcal Vaccines | Aged | Staphylococcal Infections | Medicine | Middle Aged | Virulence Factors | Research Support, Non-U.S. Gov't | Q | R | Serogroup | Coagulase | Science | Nasal Mucosa | Journal Article | Adult | Aged, 80 and over | Female | Humans | Male | Staphylococcus aureus

Staphylococcus aureus is a versatile pathogen of medical significance, using multiple virulence factors to cause disease. A prophylactic S. aureus 4-antigen (SA4Ag) vaccine comprising capsular polysaccharide (types 5 and 8) conjugates, clumping factor A (ClfA) and manga... View more
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