Increased cell wall teichoic acid production and D-alanylation are common phenotypes among daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates.

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Ute Bertsche; Soo-Jin Yang; Daniel Kuehner; Stefanie Wanner; Nagendra N Mishra; Tobias Roth; Mulugeta Nega; Alexander Schneider; Christoph Mayer; Timo Grau; Arnold S Bayer; Christopher Weidenmaier;

Multiple mechanisms have been correlated with daptomycin-resistance (DAP-R) in Staphylococcus aureus. However, one common phenotype observed in many DAP-R S. Aureus strains is a thickened cell wall (CW). The first evidence for an impact of CW-linked glycopolymers on thi... View more
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