Increased cell wall teichoic acid production and D-alanylation are common phenotypes among daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates.

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Bertsche, Ute; Yang, Soo-Jin; Kuehner, Daniel; Wanner, Stefanie; Mishra, Nagendra N.; Roth, Tobias; Nega, Mulugeta; Schneider, Alexander; Mayer, Christoph; Grau, Timo; Bayer, Arnold S.; Weidenmaier, Christopher;

Multiple mechanisms have been correlated with daptomycin-resistance (DAP-R) in Staphylococcus aureus. However, one common phenotype observed in many DAP-R S. Aureus strains is a thickened cell wall (CW). The first evidence for an impact of CW-linked glycopolymers on thi... View more
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