publication . Article . 2012

P01.33. A new development of Triterpene Acids- containing extracts from Viscum album L. displays synergistic induction of apoptosis in childhood leukemia

Delebinski C; Jäger S; Kauczor G; Kemnitz-Hassanin K; Seeger K; Henze G; Lode H; Seifert G;
Open Access
  • Published: 01 Jun 2012 Journal: BMC Complementary and Alternative Medicine, volume 12 (eissn: 1472-6882, Copyright policy)
  • Publisher: Springer Nature
Abstract
Purpose Aqueous Viscum album L. extracts (VAE) are widely used in complementary cancer therapies. Due to their low solubility, triterpene acids, which are known to possess anti-cancer properties, do not occur in aqueous extracts in significant amounts. Using cyclodextrins it was possible to solubilize mistletoe triterpene acids and to determine the anti-cancer properties in different acute lymphoblastic (ALL) and myeloid leukemia cell lines (AML). Methods The experimental extracts contain either mistletoe lectin-I and viscotoxins (viscum) or solubilized oleanolicand betulinic acids (TT) and more interestingly, a combination thereof (viscumTT). The cytotoxicity o...
Subjects
free text keywords: Complementary and alternative medicine, General Medicine, Traditional medicine, Cytotoxicity, Molecular biology, In vivo, Apoptosis, Betulinic acid, chemistry.chemical_compound, chemistry, Viscum album, biology.organism_classification, biology, Annexin, Physical therapy, medicine.medical_specialty, medicine, Viscum, business.industry, business, Viscotoxins, Poster Presentation, Other systems of medicine, RZ201-999
Funded by
NIH| International Research Conference on Integrative Medicine
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 3R13AT007128-01S1
  • Funding stream: NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE
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