publication . Article . 2016

Identity-by-descent estimation with population- and pedigree-based imputation in admixed family data

Mohamad Saad; Alejandro Q. Nato; Fiona L. Grimson; Steven M. Lewis; Lisa A. Brown; Elizabeth M. Blue; Timothy A. Thornton; Elizabeth A. Thompson; Ellen M. Wijsman;
Open Access English
  • Published: 01 Oct 2016 Journal: BMC Proceedings, volume 10, issue Suppl 7, pages 295-301 (eissn: 1753-6561, Copyright policy)
  • Publisher: BioMed Central
Abstract
Background In the past few years, imputation approaches have been mainly used in population-based designs of genome-wide association studies, although both family- and population-based imputation methods have been proposed. With the recent surge of family-based designs, family-based imputation has become more important. Imputation methods for both designs are based on identity-by-descent (IBD) information. Apart from imputation, the use of IBD information is also common for several types of genetic analysis, including pedigree-based linkage analysis. Methods We compared the performance of several family- and population-based imputation methods in large pedigrees...
Subjects
free text keywords: Proceedings, General Biochemistry, Genetics and Molecular Biology, General Medicine, Genetic association, Computational biology, Pedigree chart, Genetic linkage, Identity by descent, Imputation (statistics), Genetics, Data set, Population, education.field_of_study, education, Medicine, business.industry, business
Funded by
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Methods for the Genetic Epidemiology of Complex Traits
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R37GM046255-21
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| ALZHEIMERS DISEASE RESEARCH CENTER
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5P50AG005136-21
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| Identifying Alzheimers disease genes using genomic and family data
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1K99AG040184-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
,
NIH| Sequence-based Discovery of AD Risk & Protective Alleles
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01AG049507-03
  • Funding stream: NATIONAL INSTITUTE ON AGING
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publication . Article . 2016

Identity-by-descent estimation with population- and pedigree-based imputation in admixed family data

Mohamad Saad; Alejandro Q. Nato; Fiona L. Grimson; Steven M. Lewis; Lisa A. Brown; Elizabeth M. Blue; Timothy A. Thornton; Elizabeth A. Thompson; Ellen M. Wijsman;