Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes

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Goetsch, Paul D.; Garrigues, Jacob M.; Strome, Susan;
(2017)
  • Publisher: Public Library of Science
  • Journal: PLoS Genetics,volume 13,issue 11 (issn: 1553-7390, eissn: 1553-7404)
  • Related identifiers: pmc: PMC5683655, doi: 10.1371/journal.pgen.1007088
  • Subject: Computational Biology | Caenorhabditis | Animal Models | Research Article | Eukaryota | Fertility | Sequence Motif Analysis | Epigenetics | Cell Processes | Genetics | Embryos | Chromosome Biology | Genome Analysis | Genomics | Sequence Analysis | Animals | Multiprotein Complexes | Embryology | Experimental Organism Systems | Database and Informatics Methods | Repressor Proteins | Phenotype | Caenorhabditis elegans Proteins | Biology and Life Sciences | RNA | Embryo, Nonmammalian | Developmental Biology | Research and Analysis Methods | Nematoda | Genetic interference | Caenorhabditis Elegans | Nucleic acids | Chromatin | Protein Binding | Gene Ontologies | DNA transcription | Cell Biology | Model Organisms | Biochemistry | Bioinformatics | Organisms | Invertebrates | RNA interference | Gene expression | Cell Cycle and Cell Division
    mesheuropmc: psychological phenomena and processes | humanities

The DREAM (Dp/Retinoblastoma(Rb)-like/E2F/MuvB) transcriptional repressor complex acts as a gatekeeper of the mammalian cell cycle by establishing and maintaining cellular quiescence. How DREAM's three functional components, the E2F-DP heterodimer, the Rb-like pocket pr... View more