Minimum Description Length Block Finder, a Method to Identify Haplotype Blocks and to Compare the Strength of Block Boundaries

Article, Other literature type English OPEN
Mannila, H.; Koivisto, M.; Perola, M.; Varilo, T.; Hennah, W.; Ekelund, J.; Lukk, M.; Peltonen, L.; Ukkonen, E.;
  • Publisher: The American Society of Human Genetics
  • Journal: The American Journal of Human Genetics,volume 73,issue 1,pages86-94 (issn: 0002-9297)
  • Related identifiers: pmc: PMC1180593, doi: 10.1086/376438
  • Subject: Genetics(clinical) | Genetics | Articles

We describe a new probabilistic method for finding haplotype blocks that is based on the use of the minimum description length (MDL) principle. We give a rigorous definition of the quality of a segmentation of a genomic region into blocks and describe a dynamic programm... View more
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