Selected ABCB1, ABCB4 and ABCC2 polymorphisms do not enhance the risk of drug-induced hepatotoxicity in a Spanish cohort.

Article English OPEN
Ulzurrun, Eugenia; Stephens, Camilla; Ruiz-Cabello, Francisco; Robles-Diaz, Mercedes; Saenz-López, Pablo; Hallal, Hacibe; Soriano, German; Roman, Eva; Fernandez, M. Carmen; Lucena, M. Isabel; Andrade, Raúl J.;
(2014)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 9, issue 4 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Identifiers: doi: 10.1371/journal.pone.0094675, pmc: PMC3986086
  • Subject: Genomic Medicine | Human Genetics | Research Article | Research Design | Variant genotypes | Clinical Medicine | Evolutionary Biology | Genetics | Pharmacology | Drug metabolism | Genomics | Liver Diseases | Alleles | Linkage disequilibrium | Population Genetics | Biology and Life Sciences | Drug therapy | Gastroenterology and Hepatology | Adverse Reactions | Research and Analysis Methods | Clinical Research Design | Medicine | Bile | Personalized Medicine | Q | Haplotypes | R | Genetic Testing | Clinical Genetics | Science | Cohort Studies | Bilirubin | Clinical Pharmacology | Genetic Association Studies | Medicine and Health Sciences | Genetic Polymorphism | Pharmacogenetics

[Background and Aims] Flawed ABC transporter functions may contribute to increased risk of drug-induced liver injury (DILI). We aimed to analyse the influence of genetic variations in ABC transporters on the risk of DILI development and clinical presentations in a l... View more
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