Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers

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Capo-chichi, Callinice D; Cai, Kathy Q; Xu, Xiang-Xi;
  • Publisher: BMC
  • Journal: Biomarker Research,volume 6 (issn: 2050-7771, eissn: 2050-7771)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1186/s40364-018-0144-9, pmc: PMC6208109
  • Subject: Lamin A/C degradation | Ovarian cancer | Cytoplasmic localization | Research | Active caspase-6 | RM1-950 | Therapeutics. Pharmacology | Flow cytometry | Immunofluorescence
    mesheuropmc: congenital, hereditary, and neonatal diseases and abnormalities | animal structures | integumentary system | endocrine system diseases | embryonic structures

Abstract Background In most women with ovarian cancer, the diagnosis occurs after dissemination of tumor cells beyond ovaries. Several molecular perturbations occur ahead of tumor initiation including loss of lamin A/C. Our hypothesis was that the loss of nuclear struct... View more
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