publication . Article . 2016

Safety of polyethylene glycol 3350 solution in chronic constipation: randomized, placebo-controlled trial

McGraw, Thomas;
Open Access English
  • Published: 01 Jul 2016 Journal: Clinical and Experimental Gastroenterology, volume 9, pages 173-180 (issn: 1178-7023, eissn: 1178-7023, Copyright policy)
  • Publisher: Dove Medical Press
Abstract
Thomas McGraw Global Medical Affairs, Merck & Co., Inc., Kenilworth, NJ, USA Purpose: To evaluate the safety and tolerability of aqueous solution concentrate (ASC) of polyethylene glycol (PEG) 3350 in patients with functional constipation.Patients and methods: The patients who met Rome III diagnostic criteria for functional constipation were randomized in this multicenter, randomized, placebo-controlled, single-blind study to receive once daily dose of PEG 3350 (17 g) ASC or placebo solution for 14 days. The study comprised a screening period (visit 1), endoscopy procedure (visits 2 and 3), and follow-up telephone calls 30 days...
Subjects
free text keywords: constipation, Diseases of the digestive system. Gastroenterology, RC799-869, solutions, laxatives, Clinical and Experimental Gastroenterology, polyethylene glycols, Original Research, drug tolerance
Related Organizations
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publication . Article . 2016

Safety of polyethylene glycol 3350 solution in chronic constipation: randomized, placebo-controlled trial

McGraw, Thomas;