Target Site Recognition by a Diversity-Generating Retroelement

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Guo, Huatao; Tse, Longping V.; Nieh, Angela W.; Czornyj, Elizabeth; Williams, Steven; Oukil, Sabrina; Liu, Vincent B.; Miller, Jeff F.;
(2011)
  • Publisher: Public Library of Science
  • Journal: PLoS Genetics,volume 7,issue 12 (issn: 1553-7390, eissn: 1553-7404)
  • Related identifiers: doi: 10.1371/journal.pgen.1002414, pmc: PMC3240598
  • Subject: Biotechnology | Research Article | Molecular cell biology | Genetic Mutation | Adaptation | Microbial Evolution | Evolutionary Processes | Mutagenesis | Genomic Evolution | Evolutionary Genetics | QH426-470 | Bacteriology | Genetics | Evolutionary Biology | DNA | Bacterial Evolution | DNA structure | Biology | Organismal Evolution | Microbiology | Transposons | Nucleic acids | Retrotransposons | Applied Microbiology | Mutation | Microbial Mutation | Biochemistry

Diversity-generating retroelements (DGRs) are in vivo sequence diversification machines that are widely distributed in bacterial, phage, and plasmid genomes. They function to introduce vast amounts of targeted diversity into protein-encoding DNA sequences via mutagenic ... View more