Systemic high-dose methotrexate plus ifosfamide is highly effective for central nervous system (CNS) involvement of lymphoma

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Fischer , Lars; Korfel , Agnieszka; Kiewe , Philipp; Neumann , Martin; Jahnke , Kristoph; Thiel , Eckhard;
  • Publisher: Springer Verlag
  • Related identifiers: doi: 10.1007/s00277-008-0575-8
  • Subject: Ifosfamide | Methotrexate | Neoplastic meningitis | CNS lymphoma

International audience; Patients with malignant central nervous system (CNS) involvement of lymphoma have a poor prognosis with intrathecal chemotherapy and radiation. In this paper, we report the results we obtained in such patients by intravenous chemotherapy with hig... View more
  • References (32)
    32 references, page 1 of 4

    1. Bokstein F, Lossos A, Siegal T (1998) Leptomeningeal metastases from solid tumors: a comparison of two prospective series treated with and without intra-cerebrospinal fluid chemotherapy. Cancer 82:1756-1763. doi:10.1002/(SICI)1097-0142(19980501) 82:9<1764::AID-CNCR24>3.0.CO;2-1

    2. Glantz MJ, LaFollette S, Jaeckle KA et al (1999) Randomized trial of a slow-release versus a standard formulation of cytarabine for the intrathecal treatment of lymphomatous meningitis. J Clin Oncol 17:3110-3116

    3. Glantz MJ, Jaeckle KA, Chamberlain MC et al (1999) A randomized controlled trial comparing intrathecal sustainedrelease cytarabine (DepoCyt) to intrathecal methotrexate in patients with neoplastic meningitis from solid tumors. Clin Cancer Res 5:3394-3402

    4. Grossman SA, Finkelstein DM, Ruckdeschel JC et al (1993) Randomized prospective comparison of intraventricular methotrexate and thiotepa in patients with previously untreated neoplastic meningitis. Eastern Cooperative Oncology Group. J Clin Oncol 11:561-569

    5. Bokstein F, Lossos A, Lossos IS et al (2002) Central nervous system relapse of systemic non-Hodgkin's lymphoma: results of treatment based on high-dose methotrexate combination chemotherapy. Leuk Lymphoma 43:587-593. doi:10.1080/1042819 0290012092

    6. Bollen EL, Brouwer RE, Hamers S et al (1997) Central nervous system relapse in non-Hodgkin lymphoma. A single-center study of 532 patients. Arch Neurol 54:854-859

    7. Lagerwaard FJ, Levendag PC, Nowak PJ et al (1999) Identification of prognostic factors in patients with brain metastases: a review of 1292 patients. Int J Radiat Oncol Biol Phys 43:795- 803. doi:10.1016/S0360-3016(98)00442-8

    8. van Besien K, Ha CS, Murphy S et al (1998) Risk factors, treatment, and outcome of central nervous system recurrence in adults with intermediate-grade and immunoblastic lymphoma. Blood 91:1178-1184

    9. Blaney SM, Poplack DG (1996) Pharmacologic strategies for the treatment of meningeal malignancy. Invest New Drugs 14:69-85. doi:10.1007/BF00173684

    10. Hiraga S, Arita N, Ohnishi T et al (1999) Rapid infusion of highdose methotrexate resulting in enhanced penetration into cerebrospinal fluid and intensified tumor response in primary central nervous system lymphomas. J Neurosurg 91:221-230

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