Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers

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Kyle C Wilcox; Matthew R Marunde; Aditi Das; Pauline T Velasco; Benjamin D Kuhns; Michael T Marty; Haoming Jiang; Chi-Hao Luan; Stephen G Sligar; William L Klein;

Despite their value as sources of therapeutic drug targets, membrane proteomes are largely inaccessible to high-throughput screening (HTS) tools designed for soluble proteins. An important example comprises the membrane proteins that bind amyloid β oligomers (AβOs). AβO... View more