The effect of respiration buffer composition on mitochondrial metabolism and function.

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Wollenman, Lucas C.; Vander Ploeg, Matthew R.; Miller, Mackinzie L.; Zhang, Yizhu; Bazil, Jason N.;
(2017)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 12,issue 11 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5665555, doi: 10.1371/journal.pone.0187523
  • Subject: Energy-Producing Organelles | Research Article | Respiration | Neurochemistry | Ketones | Chemical Compounds | Physical Sciences | Acids | Bioenergetics | Oxygen Consumption | Organic Chemistry | Neurotransmitters | Glutamate | Chemistry | Chlorides | Carbohydrates | Biology and Life Sciences | Disaccharides | Mitochondria | Neuroscience | Physiology | Medicine | Sucrose | Pyruvate | Q | R | Cell Biology | Cellular Structures and Organelles | Phosphates | Biochemistry | Adenine | Science | Physiological Processes | Medicine and Health Sciences | Organic Compounds | Nucleotides

Functional studies on isolated mitochondria critically rely on the right choice of respiration buffer. Differences in buffer composition can lead to dramatically different respiration rates leading to difficulties in comparing prior studies. The ideal buffer facilities ... View more
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