Poly(ADP-ribose) polymerase inhibition reveals a potential mechanism to promote neuroprotection and treat neuropathic pain

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Komirishetty, Prashanth; Areti, Aparna; Gogoi, Ranadeep; Sistla, Ramakrishna; Kumar, Ashutosh;
(2016)
  • Publisher: Medknow Publications
  • Journal: Neural Regeneration Research,volume 11,issue 10,pages1,545-1,548 (issn: 1673-5374, eissn: 1876-7958)
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  • Related identifiers: pmc: PMC5116822, doi: 10.4103/1673-5374.193222
  • Subject: neuropathic pain | Neurology. Diseases of the nervous system | neuroinflammation | bioenergetic crisis | poly(ADP-ribose) polymerase | RC346-429 | Invited Review | oxidative stress | neuropathic pain; poly(ADP-ribose) polymerase; neuroinflammation; oxidative stress; bioenergetic crisis

Neuropathic pain is triggered by the lesions to peripheral nerves which alter their structure and function. Neuroprotective approaches that limit the pathological changes and improve the behavioral outcome have been well explained in different experimental models of neu... View more
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