publication . Other literature type . Article . 2010

The Differential Role of L-Selectin and ICAM-1 in Th1-Type and Th2-Type Contact Hypersensitivity

Koichi Yanaba; Manabu Fujimoto; Thomas F. Tedder; Eiji Muroi; Asako Ogawa; Toshihide Hara; Minoru Hasegawa; Ayumi Yoshizaki; Fumihide Ogawa; Motoi Takenaka; ...
Open Access English
  • Published: 01 Jun 2010
Abstract
Sensitization and challenge using dinitrofluorobenzene (DNFB) induce contact hypersensitivity (CHS) with predominant type 1 helper (Th1) cell infiltration, while those using fluorescein isothiocyanate (FITC) generate CHS with Th2 cell infiltration. CHS results from inflammatory cell infiltration, a process highly regulated by expression of multiple adhesion molecules. To determine a role of L-selectin and intercellular adhesion molecule-1 (ICAM-1) in Th1- and Th2-type CHS, CHS induced by DNFB or FITC in mice lacking L-selectin, ICAM-1 (ICAM-1−/−), or both. Th1-type CHS induced by DNFB was inhibited by L-selectin and/or ICAM-1 deficiency, which was associated wit...
Subjects
Medical Subject Headings: integumentary systemskin and connective tissue diseases
free text keywords: Article, Cell Biology, Biochemistry, Molecular Biology, Dermatology, Cell, medicine.anatomical_structure, medicine, ICAM-1, Biology, L-selectin, biology.protein, Cell migration, Immunoglobulin E, Sensitization, Cell adhesion molecule, Interferon gamma, medicine.drug
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