Tumor suppressor genes that escape from X-inactivation contribute to cancer sex bias

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Dunford, Andrew ; Weinstock, David M. ; Savova, Virginia ; Schumacher, Steven E. ; Cleary, John P. ; Yoda, Akinori ; Sullivan, Timothy J. ; Hess, Julian M. ; Gimelbrant, Alexander A. ; Beroukhim, Rameen ; Lawrence, Michael S. ; Getz, Gad ; Lane, Andrew A. (2016)

There is a striking and unexplained male predominance across many cancer types. A subset of X chromosome (chrX) genes can escape X-inactivation, which would protect females from complete functional loss by a single mutation. To identify putative “Escape from X-Inactivat... View more
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