FHL1 activates myostatin signalling in skeletal muscle and promotes atrophy

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Lee, Jen Y.; Lori, Dede; Wells, Dominic J.; Kemp, Paul R.;
  • Publisher: Elsevier
  • Journal: FEBS Open Bio,volume 5,pages753-762 (eissn: 2211-5463)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4576159, doi: 10.1016/j.fob.2015.08.011
  • Subject: Research article | VEGF-C, vascular endothelial growth factor C | FHL1 | Fibre type | GDF-15, growth and differentiation factor 15 | MHC, myosin heavy chain | PAI-1, plasminogen activator inhibitor 1 | Muscle wasting | Myostatin | TGF-β, transforming growth factor beta | Mouse | TA, tibialis anterior | FHL1, four and a half LIM domain protein 1 | COPD, chronic obstructive pulmonary disease
    mesheuropmc: musculoskeletal system

Myostatin is a TGFβ family ligand that reduces muscle mass. In cancer cells, TGFβ signalling is increased by the protein FHL1. Consequently, FHL1 may promote signalling by myostatin. We therefore tested the ability of FHL1 to regulate myostatin function. FHL1 increased ... View more
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