Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial.

Article English OPEN
Kremsner, PG; Adegnika, AA; Hounkpatin, AB; Zinsou, JF; Taylor, TE; Chimalizeni, Y; Liomba, A; Kombila, M; Bouyou-Akotet, MK; Mawili Mboumba, DP; Agbenyega, T; Ansong, D; Sylverken, J; Ogutu, BR; Otieno, GA; Wangwe, A; Bojang, KA; Okomo, U; Sanya-Isijola, F; Newton, CR; Njuguna, P; Kazungu, M; Kerb, R; Geditz, M; Schwab, M; Velavan, TP; Nguetse, C; Köhler, C; Issifou, S; Bolte, S; ... view all 33 authors (2016)
  • Publisher: Public Library of Science
  • Journal: PLoS Medicine,volume 13,issue 1 (issn: 1549-1277, eissn: 1549-1676)
  • Related identifiers: pmc: PMC4710539, doi: 10.1371/journal.pmed.1001938
  • Subject: R | Research Article | Medicine
    mesheuropmc: parasitic diseases

Editors' Summary Background Globally, about 200 million cases of malaria—a mosquito-borne parasitic disease—occur every year. Malaria infections, which can be caused by several parasites, can be “uncomplicated” or “severe.” Prompt treatment of uncomplicated malaria, whi... View more
  • References (35)
    35 references, page 1 of 4

    1. Kremsner PG, Taylor T, Issifou S, Kombila M, Chimalizeni Y, Kawaza K, et al. A simplified intravenous artesunate regimen for severe malaria. J Infect Dis. 2012; 205:312-319. doi: 10.1093/infdis/jir724 PMID: 22180622

    2. World Health Organization. Guidelines for the treatment of malaria. Geneva: World Health Organization; 2015.

    3. Krishna S, Planche T, Agbenyega T, Woodrow C, Agranoff D, Bedu-Addo G, et al. Bioavailability and preliminary clinical efficacy of intrarectal artesunate in Ghanaian children with moderate malaria. Antimicrob Agents Chemother. 2001; 45:509-516. PMID: 11158748

    4. Nealon C, Dzeing A, Muller-Romer U, Planche T, Sinou V, Kombila M, et al. Intramuscular bioavailability and clinical efficacy of artesunate in gabonese children with severe malaria. Antimicrob Agents Chemother. 2002; 46:3933-3939. PMID: 12435698

    5. Dondorp AM, Maude RJ, Hendriksen IC, Day NP, White NJ. Artesunate dosing in severe falciparum malaria. J Infect Dis. 2012; 206:618-619. doi: 10.1093/infdis/jis389 PMID: 22732917

    6. Kremsner PG, Taylor T, Issifou S, Kombila M, Chimalizeni Y, Kawaza K, et al. A simplified intravenous artesunate regimen for severe malaria-reply. J Infect Dis. 2012; 206:621-622.

    7. Kremsner PG, Valim C, Missinou MA, Olola C, Krishna S, Issifou S, et al. Prognostic value of circulating pigmented cells in African children with malaria. J Infect Dis. 2009; 199:142-150. doi: 10.1086/595295 PMID: 19086817

    8. Taylor T, Olola C, Valim C, Agbenyega T, Kremsner P, Krishna S, et al. Standardized data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network. Trans R Soc Trop Med Hyg. 2006; 100:615-622. PMID: 16551469

    9. World Health Organization. Management of severe malaria: a practical handbook- 3rd ed. Available: Accessed 3 December 2015.

    10. White NJ, Looareesuwan S, Warrell DA, Warrell MJ, Chanthavanich P, Bunnag D, et al. Quinine loading dose in cerebral malaria. Am J Trop Med Hyg. 1983; 32:1-5.

  • Related Research Results (2)
  • Metrics
    views in OpenAIRE
    views in local repository
    downloads in local repository

    The information is available from the following content providers:

    FromNumber Of ViewsNumber Of Downloads
    St George's Online Research Archive - IRUS-UK 0 2
Share - Bookmark