Creatine salts provide neuroprotection even after partial impairment of the creatine transporter

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Adriano, E. ; Garbati, P. ; Salis, A. ; Damonte, G. ; Millo, E. ; Balestrino, M. (2017)
  • Publisher: Elsevier Science
  • Journal: Neuroscience, volume 340, pages 299-307 (issn: 0306-4522, eissn: 1873-7544)
  • Related identifiers: pmc: PMC5231321, doi: 10.1016/j.neuroscience.2016.02.038
  • Subject: Neuroscience(all) | BBB, blood-brain barrier | creatine transporter deficiency | GPA, guanidine acetic acid | creatine glucose | CrT, creatine transporter | creatine | neuroprotection | TLC, thin layer chromatography | creatine ascorbate | Article | creatine gluconate

Creatine, a compound that is critical for energy metabolism of nervous cells, crosses the blood-brain barrier (BBB) and the neuronal plasma membrane with difficulty, and only using its specific transporter. In the hereditary condition where the creatine transporter is d... View more
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