Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis

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Chrétien , Chloé; Fenech , Claire; Liénard , Fabienne; Grall , Sylvie; Chevalier , Charlène; Chaudy , Sylvie; Brenachot , Xavier; Berges , Raymond; Louche , Katie; Stark , Romana; Nédélec , Emmanuelle; Laderrière , Amélie; Andrews , Zane B.; Benani , Alexandre; Flockerzi , Veit; Gascuel , Jean; Hartmann , Jana; Moro , Cédric; Birnbaumer , Lutz; Leloup , Corinne; Pénicaud , Luc; Fioramonti , Xavier;
(2017)
  • Publisher: American Diabetes Association
  • Related identifiers: doi: 10.2337/db16-1114
  • Subject: Endocrinologie et métabolisme | Endocrinology and metabolism | noyau arqué | proopiomelanocortine | neuropeptide-y | prise alimentaire | skeletal-muscle | cellule endotheliale | mouse | arcuate nucleus | Food and Nutrition | Médecine humaine et pathologie | proopiomelanocortin neurons | [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition | arcuate nucleus;food-intake;synaptic-transmission;endothelial-cell;skeletal-muscle;cation channel;neuropeptide-y;ion channel;mouse;proopiomelanocortin neuron | muscle squelettique | synaptic-transmission | Alimentation et Nutrition | neuropeptide y | endothelial-cells | canal ionique | ion channels | souris | cation channels | food-intake | Human health and pathology | transmission synaptique | neurone

International audience; The mediobasal hypothalamus (MBH) contains neurons capable of directly detecting metabolic signals such as glucose to control energy homeostasis. Among them, glucose-excited (GE) neurons increase their electrical activity when glucose rises. In v... View more