Drug Elucidation: Invertebrate Genetics Sheds New Light on the Molecular Targets of CNS Drugs

Article English OPEN
Dwyer, Donard S.; Aamodt, Eric; Cohen, Bruce; Buttner, Edgar A.;
(2014)

Many important drugs approved to treat common human diseases were discovered by serendipity, without a firm understanding of their modes of action. As a result, the side effects and interactions of these medications are often unpredictable, and there is limited guidanc... View more
  • References (139)
    139 references, page 1 of 14

    Antkowiak B. (2001). How do general anaesthetics work? Naturwissenschaften 88 201–213. 10.1007/s001140100230

    Bendz H. Aurell M. (1999). Drug-induced diabetes insipidus: incidence, prevention and management. Drug Saf. 21 449–456. 10.2165/00 002018-199921060-00002

    Berger Z. Ttofi E. K. Michel C. H. Pasco M. Y. Tenant S. Rubinsztein D. C. (2005). Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway. Hum. Mol. Genet. 14 3003–3011. 10.1093/hmg/ddi331

    Bhandari P. Hill J. S. Farris S. P. Costin B. Martin I. Chan C.-L. (2012). Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice. Genes Brain Behav. 11 387–397. 10.1111/j.1601-183X.2012.00765.x

    Bhat S. Dao D. T. Terrillion C. E. Arad M. Smith R. J. Soldatoy N. M. (2012). CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. Prog. Neurobiol. 99 1–14. 10.1016/j.pneurobio.2012.06.001

    Brüstle M. Beck B. Schindler T. King W. Mitchell T. Clark T. (2002). Descriptors, physical properties, and drug likeness. J. Med. Chem. 45 3345–3355. 10.1021/jm011027b

    Buck K. J. Amara S. G. (1995). Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants. Mol. Pharmacol. 48 1030–1037.

    Can A. Schulze T. G. Gould T. D. (2014). Molecular actions and clinical pharmacogenetics of lithium therapy. Pharmacol. Biochem. Behav. 10.1016/j.pbb.2014.02.004 [Epub ahead of print].

    Carlsson A. (1974). Antipsychotic drugs and catecholamine synapses. J. Psychiatr. Res. 11 57–64. 10.1016/0022-3956(74)90070-3

    Carvelli L. McDonald P. W. Blakely R. D. Defelice L. J. (2004). Dopamine transporters depolarize neurons by a channel mechanism. Proc. Natl. Acad. Sci. U.S.A. 101 16046–16051. 10.1073/pnas.0403299101

  • Related Research Results (3)
  • Metrics
Share - Bookmark