Estimating the causal influence of body mass index on risk of Parkinson disease:A Mendelian randomisation study

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, ; Noyce, Alastair J. ; Kia, Demis A. ; Hemani, Gibran ; Nicolas, Aude ; Price, T. Ryan ; De Pablo-Fernandez, Eduardo ; Haycock, Philip C. ; Lewis, Patrick A. ; Foltynie, Thomas ; Davey Smith, George ; Schrag, Anette ; Lees, Andrew J. ; Hardy, John ; Singleton, Andrew ; Nalls, Mike A. ; Pearce, Neil ; Lawlor, Debbie A. ; Wood, Nicholas W. (2017)
  • Publisher: Public Library of Science
  • Journal: volume 14, issue 6 (issn: 1549-1277, eissn: 1549-1676)
  • Related identifiers: pmc: PMC5469450, doi: 10.1371/journal.pmed.1002314
  • Subject: Computational Biology | Human Genetics | Research Article | Mathematics | Research Design | Sociology | Mathematical and Statistical Techniques | Body Weight | Neurodegenerative Diseases | Genetics | Physical Sciences | Genome Analysis | Public and Occupational Health | Genomics | Observational Studies | Neurology | Statistics (Mathematics) | Biology and Life Sciences | Genetics of Disease | /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 | Body Mass Index | Research and Analysis Methods | Physiology | Meta-Analysis | Medicine | Parkinson Disease | Consortia | Physical Activity | R | Physiological Parameters | Social Sciences | Journal Article | Medicine and Health Sciences | Movement Disorders | Genome-Wide Association Studies | Statistical Methods

Background<br/><br/>Both positive and negative associations between higher body mass index (BMI) and Parkinson disease (PD) have been reported in observational studies, but it has been difficult to establish causality because of the possibility of residual confounding o... View more