publication . Article . Other literature type . 2018

Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.

Aleksandr Milshteyn; Nathaniel R. Braffman; Allison Fay; John B. Biggins; Mirjana Lilic; Sean F. Brady; James Peek; Seth A. Darst; Ian D. Woodworth; Michael S. Glickman; ...
Open Access
  • Published: 01 Oct 2018
  • Publisher: Springer Nature America, Inc
Abstract
Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant bacteria through a distinct mechanism.
Subjects
Medical Subject Headings: polycyclic compounds
free text keywords: Science, Q, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, Article, Gene, Rifamycin, Bacteria, biology.organism_classification, biology, Phenotype, Polymerase, biology.protein, Microbiology, Antibiotics, medicine.drug_class, medicine, In vivo, Transcription (biology)
Funded by
NIH| Discovery of Antibiotics from Soil Microbiomes Using Metagenomics
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R35GM122559-01
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Structure/function analyses of essential mycobacterial transcription regulators
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM114450-02
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| NE-CAT Center for Advanced Macromolecular Crystallography
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 4P41GM103403-14
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| A minimally invasive synthetic bio-driven approach for natural products discovery
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01GM110714-01A1
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
75 references, page 1 of 5

Chakraborty, S, Rhee, KY. Tuberculosis drug development: history and evolution of the mechanism-based paradigm. Cold Spring Harb. Perspect. Med. 2015; 5: a021147 [OpenAIRE] [PubMed] [DOI]

Zumla, A. The WHO 2014 Global tuberculosis report—further to go. Lancet Glob. Health. 2015; 3: e10-e12 [PubMed] [DOI]

Ramaswamy, S, Musser, JM. Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber. Lung Dis.. 1998; 79: 3-29 [OpenAIRE] [PubMed] [DOI]

Perron, GG. Functional characterization of bacteria isolated from ancient arctic soil exposes diverse resistance mechanisms to modern antibiotics. PLoS One. 2015; 10: e0069533 [OpenAIRE] [PubMed] [DOI]

D’Costa, VM. Antibiotic resistance is ancient. Nature. 2011; 477: 457-461 [OpenAIRE] [PubMed] [DOI]

Bhullar, K. Antibiotic resistance is prevalent in an isolated cave microbiome. PLoS One. 2012; 7: e34953 [OpenAIRE] [PubMed] [DOI]

Dawson, S, Malkinson, JP, Paumier, D, Searcey, M. Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies. Nat. Prod. Rep.. 2007; 24: 109-126 [OpenAIRE] [PubMed] [DOI]

Kahne, D, Leimkuhler, C, Lu, W, Walsh, C. Glycopeptide and lipoglycopeptide antibiotics. Chem. Rev.. 2005; 105: 425-448 [OpenAIRE] [PubMed] [DOI]

Strieker, M, Marahiel, MA. The structural diversity of acidic lipopeptide antibiotics. Chembiochem. 2009; 10: 607-616 [OpenAIRE] [PubMed] [DOI]

Roesch, LF. Pyrosequencing enumerates and contrasts soil microbial diversity. ISME J.. 2007; 1: 283-290 [OpenAIRE] [PubMed] [DOI]

Daniel, R. The metagenomics of soil. Nat. Rev. Microbiol. 2005; 3: 470-478 [OpenAIRE] [PubMed] [DOI]

Milshteyn, A, Schneider, JS, Brady, SF. Mining the metabiome: identifying novel natural products from microbial communities. Chem. Biol.. 2014; 21: 1211-1223 [OpenAIRE] [PubMed] [DOI]

Reddy, BV. Natural product biosynthetic gene diversity in geographically distinct soil microbiomes. Appl. Environ. Microbiol. 2012; 78: 3744-3752 [OpenAIRE] [PubMed] [DOI]

Floss, HG, Yu, TW, Arakawa, K. The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review. J. Antibiot.. 2011; 64: 35-44 [OpenAIRE] [PubMed] [DOI]

Wang, HX. PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA-containing natural products in actinomycetes. J. Appl. Microbiol. 2013; 115: 77-85 [OpenAIRE] [PubMed] [DOI]

75 references, page 1 of 5
Abstract
Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant bacteria through a distinct mechanism.
Subjects
Medical Subject Headings: polycyclic compounds
free text keywords: Science, Q, General Biochemistry, Genetics and Molecular Biology, General Physics and Astronomy, General Chemistry, Article, Gene, Rifamycin, Bacteria, biology.organism_classification, biology, Phenotype, Polymerase, biology.protein, Microbiology, Antibiotics, medicine.drug_class, medicine, In vivo, Transcription (biology)
Funded by
NIH| Discovery of Antibiotics from Soil Microbiomes Using Metagenomics
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R35GM122559-01
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| Structure/function analyses of essential mycobacterial transcription regulators
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM114450-02
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| NE-CAT Center for Advanced Macromolecular Crystallography
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 4P41GM103403-14
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| A minimally invasive synthetic bio-driven approach for natural products discovery
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01GM110714-01A1
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
,
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
75 references, page 1 of 5

Chakraborty, S, Rhee, KY. Tuberculosis drug development: history and evolution of the mechanism-based paradigm. Cold Spring Harb. Perspect. Med. 2015; 5: a021147 [OpenAIRE] [PubMed] [DOI]

Zumla, A. The WHO 2014 Global tuberculosis report—further to go. Lancet Glob. Health. 2015; 3: e10-e12 [PubMed] [DOI]

Ramaswamy, S, Musser, JM. Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update. Tuber. Lung Dis.. 1998; 79: 3-29 [OpenAIRE] [PubMed] [DOI]

Perron, GG. Functional characterization of bacteria isolated from ancient arctic soil exposes diverse resistance mechanisms to modern antibiotics. PLoS One. 2015; 10: e0069533 [OpenAIRE] [PubMed] [DOI]

D’Costa, VM. Antibiotic resistance is ancient. Nature. 2011; 477: 457-461 [OpenAIRE] [PubMed] [DOI]

Bhullar, K. Antibiotic resistance is prevalent in an isolated cave microbiome. PLoS One. 2012; 7: e34953 [OpenAIRE] [PubMed] [DOI]

Dawson, S, Malkinson, JP, Paumier, D, Searcey, M. Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies. Nat. Prod. Rep.. 2007; 24: 109-126 [OpenAIRE] [PubMed] [DOI]

Kahne, D, Leimkuhler, C, Lu, W, Walsh, C. Glycopeptide and lipoglycopeptide antibiotics. Chem. Rev.. 2005; 105: 425-448 [OpenAIRE] [PubMed] [DOI]

Strieker, M, Marahiel, MA. The structural diversity of acidic lipopeptide antibiotics. Chembiochem. 2009; 10: 607-616 [OpenAIRE] [PubMed] [DOI]

Roesch, LF. Pyrosequencing enumerates and contrasts soil microbial diversity. ISME J.. 2007; 1: 283-290 [OpenAIRE] [PubMed] [DOI]

Daniel, R. The metagenomics of soil. Nat. Rev. Microbiol. 2005; 3: 470-478 [OpenAIRE] [PubMed] [DOI]

Milshteyn, A, Schneider, JS, Brady, SF. Mining the metabiome: identifying novel natural products from microbial communities. Chem. Biol.. 2014; 21: 1211-1223 [OpenAIRE] [PubMed] [DOI]

Reddy, BV. Natural product biosynthetic gene diversity in geographically distinct soil microbiomes. Appl. Environ. Microbiol. 2012; 78: 3744-3752 [OpenAIRE] [PubMed] [DOI]

Floss, HG, Yu, TW, Arakawa, K. The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review. J. Antibiot.. 2011; 64: 35-44 [OpenAIRE] [PubMed] [DOI]

Wang, HX. PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA-containing natural products in actinomycetes. J. Appl. Microbiol. 2013; 115: 77-85 [OpenAIRE] [PubMed] [DOI]

75 references, page 1 of 5
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