Comparing ESC and iPSC—Based Models for Human Genetic Disorders

Article English OPEN
Tomer Halevy ; Achia Urbach (2014)
  • Publisher: MDPI AG
  • Journal: Journal of Clinical Medicine, volume 3, issue 4, pages 1,146-1,162 (issn: 2077-0383, eissn: 2077-0383)
  • Related identifiers: pmc: PMC4470175, doi: 10.3390/jcm3041146
  • Subject: R | embryonic stem cells (ESCs) | induced pluripotent stem cells (iPSCs) | Review | disease modeling | Medicine

Traditionally, human disorders were studied using animal models or somatic cells taken from patients. Such studies enabled the analysis of the molecular mechanisms of numerous disorders, and led to the discovery of new treatments. Yet, these systems are limited or eve... View more
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