High Frequency of a Single Nucleotide Substitution (c.-6-180T>G) of the Canine MDR1/ABCB1 Gene Associated with Phenobarbital-Resistant Idiopathic Epilepsy in Border Collie Dogs

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Mizukami, Keijiro; Yabuki, Akira; Chang, Hye-Sook; Uddin, Mohammad Mejbah; Rahman, Mohammad Mahbubur; Kushida, Kazuya; Kohyama, Moeko; Yamato, Osamu;
  • Publisher: Hindawi Publishing Corporation
  • Journal: Disease Markers,volume 35,issue 6,pages669-672 (issn: 0278-0240, eissn: 1875-8630)
  • Related identifiers: doi: 10.1155/2013/695918, pmc: PMC3834651
  • Subject: Research Article | R5-920 | Medicine (General) | Article Subject

A single nucleotide substitution (c.-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy. In the present study, a PCR-restriction fragment length polymorphism assay was dev... View more
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