Crosslinked hydrogels—a promising class of insoluble solid molecular dispersion carriers for enhancing the delivery of poorly soluble drugs

Article English OPEN
Dajun D. Sun ; Ping I. Lee (2014)
  • Publisher: Elsevier
  • Journal: Acta Pharmaceutica Sinica B, volume 4, issue 1, pages 26-36 (issn: 2211-3835, eissn: 2211-3843)
  • Related identifiers: doi: 10.1016/j.apsb.2013.12.002, pmc: PMC4590291
  • Subject: RM1-950 | Kinetic solubility | Therapeutics. Pharmacology | Review | Crosslinked hydrogels | Supersaturation | Amorphous solid dispersions | Poly(2-hydroxyethylmethacrylate)

Water-insoluble materials containing amorphous solid dispersions (ASD) are an emerging category of drug carriers which can effectively improve dissolution kinetics and kinetic solubility of poorly soluble drugs. ASDs based on water-insoluble crosslinked hydrogels have u... View more
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