publication . Article . Other literature type . 1997

ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.

Horiuchi, Horiuchi; Silverman, Neal; Piña, Benjamín; Marcus, Gregory A.; Guarente, Leonard;
Open Access English
  • Published: 01 Jun 1997
  • Publisher: American Society for Microbiology
Abstract
The ADA genes encode factors which are proposed to function as transcriptional coactivators. Here we describe the cloning, sequencing, and initial characterization of a novel ADA gene, ADA1. Similar to the previously isolated ada mutants, ada1 mutants display decreases in transcription from various reporters. Furthermore, ADA1 interacts with the other ADAs in the ADA/GCN5 complex as demonstrated by partial purification of the complex and immunoprecipitation experiments. We estimate that the complex has a molecular mass of approximately 2 MDa. Previously, it had been demonstrated that ada5 mutants displayed more severe phenotypic defects than the other ada mutant...
Subjects
mesheuropmc: enzymes and coenzymes (carbohydrates)immune system diseaseshemic and immune systemsnutritional and metabolic diseases
free text keywords: Research Article
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publication . Article . Other literature type . 1997

ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.

Horiuchi, Horiuchi; Silverman, Neal; Piña, Benjamín; Marcus, Gregory A.; Guarente, Leonard;