Anti-amyloid-β-mediated positron emission tomography imaging in Alzheimer's disease mouse brains.

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Daniel McLean; Michael J Cooke; Yuanfei Wang; David Green; Paul E Fraser; Peter St George-Hyslop; Molly S Shoichet;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 7,issue 12 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0051958, pmc: PMC3528731
  • Subject: Alzheimer Disease | Biotechnology | Research Article | Biology | Biomedical Engineering | Neuroscience | Medicine | Engineering | Bioengineering | Neuroimaging | Q | R | Medical Devices | Drugs and Devices | Science | Dementia | Pet | Neurology

Antibody-mediated imaging of amyloid β (Aβ) in Alzheimer's disease (AD) offers a promising strategy to detect and monitor specific Aβ species, such as oligomers, that have important pathological and therapeutic relevance. The major current limitation of antibodies as a ... View more
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