publication . Article . 2015

UV-curable gel formulations: Potential drug carriers for the topical treatment of nail diseases

Kerai, Laxmi Valji; Hilton, Stephen; Murdan, Sudaxshina;
Open Access English
  • Published: 01 Aug 2015 Journal: International Journal of Pharmaceutics, volume 492, issue 1-2, pages 177-190 (issn: 0378-5173, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Nail diseases are common, cause significant distress and treatments are far from successful. Our aim was to investigate the potential of UV-curable gels - currently used as cosmetics - as topical drug carriers for their treatment. These formulations have a long residence on the nail, which is expected to increase patient compliance and the success of topical therapy. The gels are composed of the diurethane dimethacrylate, ethyl methacrylate, 2-hydroxy-2-methylpropiophenone, an antifungal drug (amorolfine HCl or terbinafine HCl) and an organic liquid (ethanol or NMP) as drug solvent. Following its application to a substrate and exposure to a UVA lamp for 2 min, t...
Subjects
free text keywords: Acrylates, Onychomycosis, Permeation, Release, UV gel, Ungual, Administration, Topical, Antifungal Agents, Chemistry, Pharmaceutical, Drug Carriers, Drug Liberation, Ethanol, Gels, Humans, Methacrylates, Methylmethacrylates, Morpholines, Nail Diseases, Nails, Naphthalenes, Propiophenones, Pyrrolidinones, Ultraviolet Rays, Urethane, Pharmaceutical Science
49 references, page 1 of 4

Alina, M., Martin, A.W., 2013. Risk of skin cancer associated with the use of UV nail lamp. J. Invest. Dermatol. 133, 1097-1099.

Arrese, J.E., Piérard, G.E., 2003. Treatment failures and relapses in onychomycosis: a stubborn clinical problem. Dermatology 207, 255-260.

Baran, R., Hay, R., Haneke, E., Tosti, A., 2006. Onychomycosis: The Current Approach to Diagnosis and Therapy. Taylor & Francis, Abingdon.

Barel, A.O., Paye, M., Maibach, H.I., Barel, A.O., Maibach, H., Maibach, H.I., 2009. Handbook of Cosmetic Science and Technology, In: André Barel, O., Marc Paye, Howard I. Maibach (Eds.), third ed. Informa Healthcare USA, New York, New York.

Chattopadhyay, D.K., Webster, D.C., 2009. Thermal stability and flame retardancy of polyurethanes. Prog. Polym. Sci. 34, 1068-1133.

Cravo, M., Cardoso, J.C., Gonçalo, M., Figueiredo, A., 2008. Allergic contact dermatitis from photobonded acrylic gel nails: a review of four cases. Contact Dermatitis 59, 250-251. [OpenAIRE]

Daniel, R.C., 2013. Onychomycosis: burden of disease and the role of topical antifungal treatment. Drugs Dermatol. 12, 1263-1266.

Dowdy, J.C., Sayre, R.M., 2013. Photobiological safety evaluation of UV nail lamps. Photochem. Photobiol. 89, 961-967.

Draelos, Z.D., 2010. Cosmetic Dermatology: Products and Procedures. WileyBlackwell, Oxford.

Elsayed, M.M.A., 2015. Development of topical therapeutics for management of onychomycosis and other nail disorders: a pharmaceutical perspective. J. Controlled Release 199, 132-144.

Erdmann, S.M., Sachs, B., Merk, H.F., 2001. Adverse reactions to sculptured nails. Allergy 56, 581-582.

Fisher, A.A., 1990. Adverse nail reactions and paresthesia from Photobonded Acrylate 'Sculptured' Nails. Cutis 293-294.

Gupta, A.K., Konnikov, N., Macdonald, P., Rich, P., Rodger, N.W., Edmonds, M.W., McManus, R., Summerbell, R.C., 1998. Prevalence and epidemiology of toenail onychomycosis in diabetic subjects: a multicentre survey. British Journal of Dermatology 139, 665-671.

Gupta, A., 2012. Examination of cure and relapse of dermatophyte toenail onychomycosis during long-term follow-up after oral therapy. J. Am. Acad. Dermatol. AB119.

Gupta, A.K., Jain, H.C., Lynde, C.W., Watteel, G.N., Summerbell, R.C., 1997. Prevalence and epidemiology of unsuspected onychomycosis in patients visiting dermatologists' offices in Ontario, Canada - a multicenter survey of 2001 patients. Int. J. Dermatol. 36, 783-787.

49 references, page 1 of 4
Similar Outcomes
12 research outcomes, page 1 of 2
12 research outcomes, page 1 of 2
Abstract
Nail diseases are common, cause significant distress and treatments are far from successful. Our aim was to investigate the potential of UV-curable gels - currently used as cosmetics - as topical drug carriers for their treatment. These formulations have a long residence on the nail, which is expected to increase patient compliance and the success of topical therapy. The gels are composed of the diurethane dimethacrylate, ethyl methacrylate, 2-hydroxy-2-methylpropiophenone, an antifungal drug (amorolfine HCl or terbinafine HCl) and an organic liquid (ethanol or NMP) as drug solvent. Following its application to a substrate and exposure to a UVA lamp for 2 min, t...
Subjects
free text keywords: Acrylates, Onychomycosis, Permeation, Release, UV gel, Ungual, Administration, Topical, Antifungal Agents, Chemistry, Pharmaceutical, Drug Carriers, Drug Liberation, Ethanol, Gels, Humans, Methacrylates, Methylmethacrylates, Morpholines, Nail Diseases, Nails, Naphthalenes, Propiophenones, Pyrrolidinones, Ultraviolet Rays, Urethane, Pharmaceutical Science
49 references, page 1 of 4

Alina, M., Martin, A.W., 2013. Risk of skin cancer associated with the use of UV nail lamp. J. Invest. Dermatol. 133, 1097-1099.

Arrese, J.E., Piérard, G.E., 2003. Treatment failures and relapses in onychomycosis: a stubborn clinical problem. Dermatology 207, 255-260.

Baran, R., Hay, R., Haneke, E., Tosti, A., 2006. Onychomycosis: The Current Approach to Diagnosis and Therapy. Taylor & Francis, Abingdon.

Barel, A.O., Paye, M., Maibach, H.I., Barel, A.O., Maibach, H., Maibach, H.I., 2009. Handbook of Cosmetic Science and Technology, In: André Barel, O., Marc Paye, Howard I. Maibach (Eds.), third ed. Informa Healthcare USA, New York, New York.

Chattopadhyay, D.K., Webster, D.C., 2009. Thermal stability and flame retardancy of polyurethanes. Prog. Polym. Sci. 34, 1068-1133.

Cravo, M., Cardoso, J.C., Gonçalo, M., Figueiredo, A., 2008. Allergic contact dermatitis from photobonded acrylic gel nails: a review of four cases. Contact Dermatitis 59, 250-251. [OpenAIRE]

Daniel, R.C., 2013. Onychomycosis: burden of disease and the role of topical antifungal treatment. Drugs Dermatol. 12, 1263-1266.

Dowdy, J.C., Sayre, R.M., 2013. Photobiological safety evaluation of UV nail lamps. Photochem. Photobiol. 89, 961-967.

Draelos, Z.D., 2010. Cosmetic Dermatology: Products and Procedures. WileyBlackwell, Oxford.

Elsayed, M.M.A., 2015. Development of topical therapeutics for management of onychomycosis and other nail disorders: a pharmaceutical perspective. J. Controlled Release 199, 132-144.

Erdmann, S.M., Sachs, B., Merk, H.F., 2001. Adverse reactions to sculptured nails. Allergy 56, 581-582.

Fisher, A.A., 1990. Adverse nail reactions and paresthesia from Photobonded Acrylate 'Sculptured' Nails. Cutis 293-294.

Gupta, A.K., Konnikov, N., Macdonald, P., Rich, P., Rodger, N.W., Edmonds, M.W., McManus, R., Summerbell, R.C., 1998. Prevalence and epidemiology of toenail onychomycosis in diabetic subjects: a multicentre survey. British Journal of Dermatology 139, 665-671.

Gupta, A., 2012. Examination of cure and relapse of dermatophyte toenail onychomycosis during long-term follow-up after oral therapy. J. Am. Acad. Dermatol. AB119.

Gupta, A.K., Jain, H.C., Lynde, C.W., Watteel, G.N., Summerbell, R.C., 1997. Prevalence and epidemiology of unsuspected onychomycosis in patients visiting dermatologists' offices in Ontario, Canada - a multicenter survey of 2001 patients. Int. J. Dermatol. 36, 783-787.

49 references, page 1 of 4
Similar Outcomes
12 research outcomes, page 1 of 2
12 research outcomes, page 1 of 2
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publication . Article . 2015

UV-curable gel formulations: Potential drug carriers for the topical treatment of nail diseases

Kerai, Laxmi Valji; Hilton, Stephen; Murdan, Sudaxshina;