Carotenoids co-localize with hydroxyapatite, cholesterol, and other lipids in calcified stenotic aortic valves. Ex vivo Raman maps compared to histological patterns.

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Bonetti, A.; Bonifacio, A.; Mora, A. Della; Livi, U.; Marchini, M.; Ortolani, F.;
(2015)
  • Publisher: PAGEPress Publications
  • Journal: European Journal of Histochemistry,volume 59,issue 2 (issn: 1121-760X, eissn: 2038-8306)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4503973, doi: 10.4081/ejh.2015.2505
  • Subject: lipids | carotenoids | Raman microspectroscopy | valve calcification, stenosis, carotenoids, lipids, Raman microspectroscopy | Valve calcification | Original Paper | stenosis | Raman microspectroscopy. | Biology (General) | QH301-705.5 | Carotenoids; Lipids; Raman microspectroscopy; Stenosis; Valve calcification; Cell Biology; Histology; Biophysics
    mesheuropmc: macromolecular substances

<p>Unlike its application for atherosclerotic plaque analysis, Raman microspectroscopy was sporadically used to check the sole nature of bioapatite deposits in stenotic aortic valves, neglecting the involvement of accumulated lipids/lipoproteins in the calcific process.... View more
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