Bone Tumor Environment as a Potential Therapeutic Target in Ewing Sarcoma

Article English OPEN
Redini, Françoise; Heymann, Dominique;
  • Publisher: Frontiers Media S.A.
  • Journal: Frontiers in Oncology,volume 5 (issn: 2234-943X, eissn: 2234-943X)
  • Related identifiers: doi: 10.3389/fonc.2015.00279, pmc: PMC4688361
  • Subject: microenvironment | tumor bone niche | Ewing sarcoma | 3D models | RANKL | Review | bisphosphonate | bone remodeling | Oncology

Ewing sarcoma is the second most common pediatric bone tumor, with three cases per million worldwide. In clinical terms, Ewing sarcoma is an aggressive, rapidly fatal malignancy that mainly develops not only in osseous sites (85%) but also in extra-skeletal soft tissue.... View more
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