Functional effects of polymorphisms on glucocorticoid receptor modulation of human anxiogenic substance-P gene promoter activity in primary amygdala neurones

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Hay, Colin W.; Shanley, Lynne; Davidson, Scott; Cowie, Philip; Lear, Marissa; McGuffin, Peter; Riedel, Gernot; McEwan, Iain J.; MacKenzie, Alasdair;
  • Publisher: Pergamon Press
  • Journal: Psychoneuroendocrinology,volume 47,issue 100,pages43-55 (issn: 0306-4530, eissn: 1873-3360)
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  • Related identifiers: doi: 10.1016/j.psyneuen.2014.04.017, pmc: PMC4103484
  • Subject: Biological Psychiatry | Endocrine and Autonomic Systems | Glucocorticoid receptor | TAC1 promoter | Gene regulation | Single nucleotide polymorphism | Endocrinology, Diabetes and Metabolism | Stress and anxiety | Article | Endocrinology | Psychiatry and Mental health

Summary Expression or introduction of the neuropeptide substance-P (SP; encoded by the TAC1 gene in humans and Tac1 in rodents) in the amygdala induces anxiety related behaviour in rodents. In addition, pharmacological antagonism of the main receptor of SP in humans; NK... View more