Cyclic GMP-AMP Synthase is Activated by Double-stranded DNA-Induced Oligomerization

Article, Other literature type English OPEN
Li, Xin ; Shu, Chang ; Yi, Guanghui ; Chaton, Catherine T. ; Shelton, Catherine L. ; Diao, Jiasheng ; Zuo, Xiaobing ; Kao, C Cheng ; Herr, Andrew B. ; Li, Pingwei (2013)
  • Publisher: Elsevier BV
  • Journal: Immunity, volume 39, issue 6, pages 1,019-1,031 (issn: 1074-7613)
  • Related identifiers: doi: 10.1016/j.immuni.2013.10.019, pmc: PMC3886715
  • Subject: Infectious Diseases | Immunology and Allergy | Immunology | Article

Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide 2′,5′ cGAMP that binds to STING and mediates the activation of TBK1 and IRF-3. Activated IRF-3 translocates... View more
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