Cyclic GMP-AMP Synthase is Activated by Double-stranded DNA-Induced Oligomerization
Article, Other literature type
Chaton, Catherine T.
Shelton, Catherine L.
Kao, C Cheng
Herr, Andrew B.
- Publisher: Elsevier BV
Infectious Diseases | Immunology and Allergy | Immunology | Article
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide 2′,5′ cGAMP that binds to STING and mediates the activation of TBK1 and IRF-3. Activated IRF-3 translocates...