publication . Article . Review . 2016

Profile of adalimumab and its potential in the treatment of uveitis

Balevic, Stephen J; Rabinovich, C Egla;
Open Access English
  • Published: 01 Sep 2016 Journal: Drug Design, Development and Therapy, volume 10, pages 2,997-3,003 (issn: 1177-8881, eissn: 1177-8881, Copyright policy)
  • Publisher: Dove Press
Abstract
Stephen J Balevic, C Egla Rabinovich Department of Pediatric Rheumatology, Duke University Medical Center, Durham, NC, USA Abstract: Uveitis refers to the presence of intraocular inflammation, and as a strict definition compromises the iris and ciliary body anteriorly and the choroid posteriorly (the uvea). Untreated, uveitis can lead to visual loss or blindness. The etiology of uveitis can include both infectious and noninfectious (usually immune-mediated) causes, the latter of which are often mediated predominantly by Th1 CD4+ T-cells that secrete proinflammatory cytokines. Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine involved in...
Subjects
mesheuropmc: humanities
free text keywords: TNFα, RM1-950, Therapeutics. Pharmacology, Review, TNF-α, Drug Design, Development and Therapy, Uveitis, Autoimmune disease, Adalimumab
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publication . Article . Review . 2016

Profile of adalimumab and its potential in the treatment of uveitis

Balevic, Stephen J; Rabinovich, C Egla;