publication . Article . 2013

Altered Olfactory Processing of Stress-Related Body Odors and Artificial Odors in Patients with Panic Disorder

Gloria-Beatrice Wintermann; Markus Donix; Peter Joraschky; Johannes Gerber; Katja Petrowski;
Open Access English
  • Published: 01 Sep 2013 Journal: PLoS ONE, volume 8, issue 9 (issn: 1932-6203, eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science
Abstract
Background: Patients with Panic Disorder (PD) direct their attention towards potential threat, followed by panic attacks, and increased sweat production. Onés own anxiety sweat odor influences the attentional focus, and discrimination of threat or non-threat. Since olfactory projection areas overlap with neuronal areas of a panic-specific fear network, the present study investigated the neuronal processing of odors in general and of stress-related sweat odors in particular in patients with PD. Methods: A sample of 13 patients with PD with/ without agoraphobia and 13 age- and gender-matched healthy controls underwent an fMRI investigation during olfactory sti...
Subjects
mesheuropmc: nervous systempsychological phenomena and processesmusculoskeletal, neural, and ocular physiology
free text keywords: Q, R, Research Article, Science, Amygdala, Anxiety, Cingulate cortex, Olfactory receptor neurons, Peaches, Psychological stress, Sweat, Thalamus, Technical University Dresden, Publication funds, Medicine, Amygdala, Angst, Gyrus cinguli, Riechschleimhaut, Schweiß, Thalamus, TU Dresden, Publikationsfonds, ddc:610
72 references, page 1 of 5

1 Roy-Byrne P, Craske M, Stein M (2006) Panic disorder. Lancet 368: 1023–1032.16980119 [PubMed]

2 Saß H, Wittchen H-U, Zaudig M, Houben I (2003) Diagnostisches und Statistisches Manual Psychischer Störungen-Textrevision-DSM-IV-TR. Goettingen: Hogrefe.

3 van Duinen MA, Schruers KR, Maes M, Griez EJ (2007) CO2 challenge induced HPA axis activation in panic. Int J Neuropsychopharmacol 10: 797–804.17076937 [PubMed]

4 Gorman JM, Kent JM, Sullivan GM, Coplan JD (2000) Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 157: 493–505.10739407 [PubMed]

5 Van den Heuvel O, Veltman DJ, Groenewegen HJ, Witter MP, Merkelbach J, et al (2005) Disorder-specific neuroanatomical correlates of attentional bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis. Arch Gen Psychiatry 62: 922–933.16061770 [PubMed]

6 Hinton D, Pich V, Chhean D, Pollack M, Barlow D (2004) Olfactory-triggered panic attacks among cambodian refugees attending a psychiatric clinic. Gen Hosp Psychiatry 26: 390–397.15474639 [OpenAIRE] [PubMed]

7 de Carvalho MR, Dias GP, Cosci F, de Melo-Neto VL, do Nascimento Bevilaqua MC, et al (2010) Current findings of fMRI in panic disorder: contributions for the fear neurocircuitry and CBT effects. Expert Rev Neurother 10: 291–303.20136384 [PubMed]

8 Haegler K, Zernecke R, Kleemann AM, Albrecht J, Pollatos O, et al (2010) No fear no risk! Human risk behavior is affected by chemosensory anxiety signals. Neuropsychologia 48: 3901–3908.20875438 [PubMed]

9 Mujica-Parodi LR, Strey HH, Blaise F, Savoy R, Cox D, et al (2009) Chemosensory cues to conspecific emotional stress activate amygdala in humans. PLoS One 4: e6415.19641623 [OpenAIRE] [PubMed]

10 Prehn A, Ohrt A, Sojka B, Ferstl R, Pause BM (2006) Chemosensory anxiety signals augment the startle reflex in humans. Neurosci Lett 394: 127–130.16257486 [PubMed]

11 Rubin D, Botanov Y, Hajcak G, Mujica-Parodi LR (2012) Second-hand stress: inhalation of stress sweat enhances neural response to neutral faces. Soc Cogn Affect Neurosci 7: 208–212.21208988 [OpenAIRE] [PubMed]

12 Zhou W, Chen D (2008) Encoding human sexual chemosensory cues in the orbitofrontal and fusiform cortices. J Neurosci 28: 14416–14421.19118174 [OpenAIRE] [PubMed]

13 Pause B, Adolph D, Prehn-Kristensen A, Ferstl R (2009) Startle response potentiation to chemosensory anxiety signals in socially anxious individuals. Int J Psychophysiol 74: 88–92.19666058 [PubMed]

14 Ackerl K, Atzmueller M, Grammer K (2002) The scent of fear. Neuro Endocrinol Lett 23: 79–84.

15 Chen D, Haviland-Jones J (2000) Human olfactory communication of emotion. Percept Motor Skill 91: 771–781.

72 references, page 1 of 5
Abstract
Background: Patients with Panic Disorder (PD) direct their attention towards potential threat, followed by panic attacks, and increased sweat production. Onés own anxiety sweat odor influences the attentional focus, and discrimination of threat or non-threat. Since olfactory projection areas overlap with neuronal areas of a panic-specific fear network, the present study investigated the neuronal processing of odors in general and of stress-related sweat odors in particular in patients with PD. Methods: A sample of 13 patients with PD with/ without agoraphobia and 13 age- and gender-matched healthy controls underwent an fMRI investigation during olfactory sti...
Subjects
mesheuropmc: nervous systempsychological phenomena and processesmusculoskeletal, neural, and ocular physiology
free text keywords: Q, R, Research Article, Science, Amygdala, Anxiety, Cingulate cortex, Olfactory receptor neurons, Peaches, Psychological stress, Sweat, Thalamus, Technical University Dresden, Publication funds, Medicine, Amygdala, Angst, Gyrus cinguli, Riechschleimhaut, Schweiß, Thalamus, TU Dresden, Publikationsfonds, ddc:610
72 references, page 1 of 5

1 Roy-Byrne P, Craske M, Stein M (2006) Panic disorder. Lancet 368: 1023–1032.16980119 [PubMed]

2 Saß H, Wittchen H-U, Zaudig M, Houben I (2003) Diagnostisches und Statistisches Manual Psychischer Störungen-Textrevision-DSM-IV-TR. Goettingen: Hogrefe.

3 van Duinen MA, Schruers KR, Maes M, Griez EJ (2007) CO2 challenge induced HPA axis activation in panic. Int J Neuropsychopharmacol 10: 797–804.17076937 [PubMed]

4 Gorman JM, Kent JM, Sullivan GM, Coplan JD (2000) Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 157: 493–505.10739407 [PubMed]

5 Van den Heuvel O, Veltman DJ, Groenewegen HJ, Witter MP, Merkelbach J, et al (2005) Disorder-specific neuroanatomical correlates of attentional bias in obsessive-compulsive disorder, panic disorder, and hypochondriasis. Arch Gen Psychiatry 62: 922–933.16061770 [PubMed]

6 Hinton D, Pich V, Chhean D, Pollack M, Barlow D (2004) Olfactory-triggered panic attacks among cambodian refugees attending a psychiatric clinic. Gen Hosp Psychiatry 26: 390–397.15474639 [OpenAIRE] [PubMed]

7 de Carvalho MR, Dias GP, Cosci F, de Melo-Neto VL, do Nascimento Bevilaqua MC, et al (2010) Current findings of fMRI in panic disorder: contributions for the fear neurocircuitry and CBT effects. Expert Rev Neurother 10: 291–303.20136384 [PubMed]

8 Haegler K, Zernecke R, Kleemann AM, Albrecht J, Pollatos O, et al (2010) No fear no risk! Human risk behavior is affected by chemosensory anxiety signals. Neuropsychologia 48: 3901–3908.20875438 [PubMed]

9 Mujica-Parodi LR, Strey HH, Blaise F, Savoy R, Cox D, et al (2009) Chemosensory cues to conspecific emotional stress activate amygdala in humans. PLoS One 4: e6415.19641623 [OpenAIRE] [PubMed]

10 Prehn A, Ohrt A, Sojka B, Ferstl R, Pause BM (2006) Chemosensory anxiety signals augment the startle reflex in humans. Neurosci Lett 394: 127–130.16257486 [PubMed]

11 Rubin D, Botanov Y, Hajcak G, Mujica-Parodi LR (2012) Second-hand stress: inhalation of stress sweat enhances neural response to neutral faces. Soc Cogn Affect Neurosci 7: 208–212.21208988 [OpenAIRE] [PubMed]

12 Zhou W, Chen D (2008) Encoding human sexual chemosensory cues in the orbitofrontal and fusiform cortices. J Neurosci 28: 14416–14421.19118174 [OpenAIRE] [PubMed]

13 Pause B, Adolph D, Prehn-Kristensen A, Ferstl R (2009) Startle response potentiation to chemosensory anxiety signals in socially anxious individuals. Int J Psychophysiol 74: 88–92.19666058 [PubMed]

14 Ackerl K, Atzmueller M, Grammer K (2002) The scent of fear. Neuro Endocrinol Lett 23: 79–84.

15 Chen D, Haviland-Jones J (2000) Human olfactory communication of emotion. Percept Motor Skill 91: 771–781.

72 references, page 1 of 5
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2013

Altered Olfactory Processing of Stress-Related Body Odors and Artificial Odors in Patients with Panic Disorder

Gloria-Beatrice Wintermann; Markus Donix; Peter Joraschky; Johannes Gerber; Katja Petrowski;