Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia

Article, Other literature type English OPEN
Sanda, Takaomi ; Lawton, Lee N. ; Barrasa, M. Inmaculada ; Fan, Zi Peng ; Kohlhammer, Holger ; Gutierrez, Alejandro ; Ma, Wenxue ; Tatarek, Jessica ; Ahn, Yebin ; Kelliher, Michelle A. ; Jamieson, Catriona H.M. ; Staudt, Louis M. ; Young, Richard A. ; Look, A. Thomas (2012)
  • Publisher: Elsevier BV
  • Journal: Cancer Cell, volume 22, issue 2, pages 209-221 (issn: 1535-6108)
  • Related identifiers: doi: 10.1016/j.ccr.2012.06.007, pmc: PMC3422504
  • Subject: Cell Biology | Article | Cancer Research | Oncology
    mesheuropmc: hemic and lymphatic diseases

The oncogenic transcription factor TAL1/SCL is aberrantly expressed in over 40% of cases of human T-cell acute lymphoblastic leukemia (T-ALL), emphasizing its importance in the molecular pathogenesis of T-ALL. Here we identify the core transcriptional regulatory circuit... View more
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