The transient nature of Bunyamwera orthobunyavirus NSs protein expression: effects of increased stability of NSs protein on virus replication.

Article English OPEN
van Knippenberg, Ingeborg; Fragkoudis, Rennos; Elliott, Richard M.;
(2013)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 8,issue 5 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3648540, doi: 10.1371/journal.pone.0064137
  • Subject: Agricultural and Biological Sciences(all) | Animal Models | Research Article | CULTURED-CELLS | PARAMYXOVIRUSES | Mouse | INDUCTION | STAT2 | /dk/atira/pure/subjectarea/asjc/2700 | Proteins | Medicine(all) | Viral Immune Evasion | PHOSPHORYLATION | PRODUCT | Biology | Microbiology | INHIBITION | Medicine | /dk/atira/pure/subjectarea/asjc/1100 | Q | UBIQUITIN-PROTEASOME SYSTEM | Biochemistry, Genetics and Molecular Biology(all) | R | Viral classification | RNA viruses | Model Organisms | Virology | /dk/atira/pure/subjectarea/asjc/1300 | Biochemistry | Science | INTERFERON REGULATORY FACTOR-3 | MOSQUITO CELLS | QR355 Virology | Virulence Factors and Mechanisms | QR355 | Mechanisms of Resistance and Susceptibility

The NSs proteins of bunyaviruses are the viral interferon antagonists, counteracting the host's antiviral response to infection. During high-multiplicity infection of cultured mammalian cells with Bunyamwera orthobunyavirus (BUNV), NSs is rapidly degraded after reaching... View more
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