Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis.

Article, Other literature type English OPEN
Belin, P.; Le Du, Marie-Hélène; Fielding, A.; Lequin, O.; Jacquet, M.; Charbonnier, Jean-Baptiste; Lecoq, A.; Thai, Robert; Courcon, M.; Masson, C.; Dugave, C.; Genet, R.; Pernodet, Jean-Luc; Gondry, Muriel;
  • Publisher: National Academy of Sciences
  • Related identifiers: pmc: PMC2678619, doi: 10.1073/pnas.0812191106
  • Subject: [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication | [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology | [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN] | [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology | [SDV.BIO]Life Sciences [q-bio]/Biotechnology | [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology | [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology | [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM] | Biological Sciences | [CHIM.ANAL]Chemical Sciences/Analytical chemistry | [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM] | [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology

International audience; The gene encoding the cytochrome P450 CYP121 is essential for Mycobacterium tuberculosis. However, the CYP121 catalytic activity remains unknown. Here, we show that the cyclodipeptide cyclo(l-Tyr-l-Tyr) (cYY) binds to CYP121, and is efficiently c... View more
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