publication . Article . 2017

Proceedings of the ISEV symposium on “HIV, NeuroAIDS, drug abuse & EVs”

Guoku Hu; Kenneth W. Witwer; Vincent C. Bond; Norman Haughey; Fatah Kashanchi; Lynn Pulliam; Shilpa Buch;
Open Access English
  • Published: 01 Mar 2017 Journal: Journal of Extracellular Vesicles, volume 6, issue 1 (issn: 2001-3078, eissn: 2001-3078, Copyright policy)
  • Publisher: Taylor & Francis
Abstract
ABSTRACT Extracellular vesicles (EVs) are globular, membrane bound nanovesicles (30–100 nm range) that are shed both during normal cellular functioning and under pathological conditions by most cell types. In recent years, there has been significant interest in the study of these vesicles as conduits for the delivery of information between cells from both analogous and disparate tissues. Their ability to carry specialised cargo including signalling mediators, proteins, messenger RNA and miRNAs characterises these vesicles as primary facilitators of cell-to-cell communication and regulation. EVs have also been demonstrated to play important roles in the field of ...
Subjects
free text keywords: Extracellular vesicles (EVs), Cytology, Other, Meeting Report, drug abuse, human immunodeficiency virus (HIV), QH573-671, NeuroAIDS
Funded by
NIH| Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R21AI074410-01A1
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| HIV Tat & cocaine-mediated alterations in microglial migration & activation involve epigenetic reulation of miRNAs
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01DA043138-01
  • Funding stream: NATIONAL INSTITUTE ON DRUG ABUSE
,
NIH| Morehouse School of Medicine G12 Multidisciplinary Biomedical Research Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 8G12MD007602-27
  • Funding stream: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES
,
NIH| Extracellular Vesicle-Mediated Immunomodulation in HIV Infection and Nicotine Abuse
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DA040385-02
  • Funding stream: NATIONAL INSTITUTE ON DRUG ABUSE
,
NIH| Renewal Application for Clinical Research Education and Career Development (CRECD
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 8R25MD007589-10
  • Funding stream: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES
45 references, page 1 of 3

Thery, C, Zitvogel, L, Amigorena, S.. Exosomes: composition, biogenesis and function. Nat Reviews Immunol. 2002; 2 (8): 569-8

Valadi, H, Ekstrom, K, Bossios, A. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9 (6): 654-659 [PubMed]

Hu, G, Drescher, KM, Chen, XM. Exosomal miRNAs: biological properties and therapeutic potential. Front Genet. 2012; 3: 56 [OpenAIRE] [PubMed]

Hu, G, Gong, AY, Roth, AL. Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. Plos Pathog. 2013; 9 (4): e1003261 [OpenAIRE] [PubMed]

Trams, EG, Lauter, CJ, Salem, N. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim Biophys Acta. 1981; 645 (1): 63-70 [PubMed]

Pan, BT, Teng, K, Wu, C. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol. 1985; 101 (3): 942-948 [OpenAIRE] [PubMed]

Johnstone, RM, Adam, M, Hammond, JR. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem. 1987; 262 (19): 9412-9420 [PubMed]

Gupta, A, Pulliam, L. Exosomes as mediators of neuroinflammation. J Neuroinflammation. 2014; 11: 68 [OpenAIRE] [PubMed]

Schwab, A, Meyering, SS, Lepene, B. Extracellular vesicles from infected cells: potential for direct pathogenesis. Front Microbiol. 2015; 6: 1132 [OpenAIRE] [PubMed]

Hu, G, Yao, H, Chaudhuri, AD. Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction. Cell Death Dis. 2012; 3: e381 [OpenAIRE] [PubMed]

Tan, IL, McArthur, JC. HIV-associated neurological disorders: a guide to pharmacotherapy. CNS Drugs. 2012; 26 (2): 123-134 [PubMed]

Gould, SJ, Booth, AM, Hildreth, JE. The Trojan exosome hypothesis. Proc Natl Acad Sci U S A. 2003; 100 (19): 10592-10597 [OpenAIRE] [PubMed]

Mack, M, Kleinschmidt, A, Bruhl, H. Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection. Nat Med. 2000; 6 (7): 769-775 [PubMed]

Simons, M, Raposo, G. Exosomes–vesicular carriers for intercellular communication. Curr Opin Cell Biol. 2009; 21 (4): 575-581 [PubMed]

Svedberg T, Pedersen KO, Bauer JH. The ultracentrifuge. Oxford: The Clarendon Press; 1940. p. 478.

45 references, page 1 of 3
Abstract
ABSTRACT Extracellular vesicles (EVs) are globular, membrane bound nanovesicles (30–100 nm range) that are shed both during normal cellular functioning and under pathological conditions by most cell types. In recent years, there has been significant interest in the study of these vesicles as conduits for the delivery of information between cells from both analogous and disparate tissues. Their ability to carry specialised cargo including signalling mediators, proteins, messenger RNA and miRNAs characterises these vesicles as primary facilitators of cell-to-cell communication and regulation. EVs have also been demonstrated to play important roles in the field of ...
Subjects
free text keywords: Extracellular vesicles (EVs), Cytology, Other, Meeting Report, drug abuse, human immunodeficiency virus (HIV), QH573-671, NeuroAIDS
Funded by
NIH| Effect of chromatin remodelers/modifiers on HIV-1 Tat activated transcription
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R21AI074410-01A1
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| HIV Tat & cocaine-mediated alterations in microglial migration & activation involve epigenetic reulation of miRNAs
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1R01DA043138-01
  • Funding stream: NATIONAL INSTITUTE ON DRUG ABUSE
,
NIH| Morehouse School of Medicine G12 Multidisciplinary Biomedical Research Center
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 8G12MD007602-27
  • Funding stream: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES
,
NIH| Extracellular Vesicle-Mediated Immunomodulation in HIV Infection and Nicotine Abuse
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DA040385-02
  • Funding stream: NATIONAL INSTITUTE ON DRUG ABUSE
,
NIH| Renewal Application for Clinical Research Education and Career Development (CRECD
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 8R25MD007589-10
  • Funding stream: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES
45 references, page 1 of 3

Thery, C, Zitvogel, L, Amigorena, S.. Exosomes: composition, biogenesis and function. Nat Reviews Immunol. 2002; 2 (8): 569-8

Valadi, H, Ekstrom, K, Bossios, A. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007; 9 (6): 654-659 [PubMed]

Hu, G, Drescher, KM, Chen, XM. Exosomal miRNAs: biological properties and therapeutic potential. Front Genet. 2012; 3: 56 [OpenAIRE] [PubMed]

Hu, G, Gong, AY, Roth, AL. Release of luminal exosomes contributes to TLR4-mediated epithelial antimicrobial defense. Plos Pathog. 2013; 9 (4): e1003261 [OpenAIRE] [PubMed]

Trams, EG, Lauter, CJ, Salem, N. Exfoliation of membrane ecto-enzymes in the form of micro-vesicles. Biochim Biophys Acta. 1981; 645 (1): 63-70 [PubMed]

Pan, BT, Teng, K, Wu, C. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol. 1985; 101 (3): 942-948 [OpenAIRE] [PubMed]

Johnstone, RM, Adam, M, Hammond, JR. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem. 1987; 262 (19): 9412-9420 [PubMed]

Gupta, A, Pulliam, L. Exosomes as mediators of neuroinflammation. J Neuroinflammation. 2014; 11: 68 [OpenAIRE] [PubMed]

Schwab, A, Meyering, SS, Lepene, B. Extracellular vesicles from infected cells: potential for direct pathogenesis. Front Microbiol. 2015; 6: 1132 [OpenAIRE] [PubMed]

Hu, G, Yao, H, Chaudhuri, AD. Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction. Cell Death Dis. 2012; 3: e381 [OpenAIRE] [PubMed]

Tan, IL, McArthur, JC. HIV-associated neurological disorders: a guide to pharmacotherapy. CNS Drugs. 2012; 26 (2): 123-134 [PubMed]

Gould, SJ, Booth, AM, Hildreth, JE. The Trojan exosome hypothesis. Proc Natl Acad Sci U S A. 2003; 100 (19): 10592-10597 [OpenAIRE] [PubMed]

Mack, M, Kleinschmidt, A, Bruhl, H. Transfer of the chemokine receptor CCR5 between cells by membrane-derived microparticles: a mechanism for cellular human immunodeficiency virus 1 infection. Nat Med. 2000; 6 (7): 769-775 [PubMed]

Simons, M, Raposo, G. Exosomes–vesicular carriers for intercellular communication. Curr Opin Cell Biol. 2009; 21 (4): 575-581 [PubMed]

Svedberg T, Pedersen KO, Bauer JH. The ultracentrifuge. Oxford: The Clarendon Press; 1940. p. 478.

45 references, page 1 of 3
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publication . Article . 2017

Proceedings of the ISEV symposium on “HIV, NeuroAIDS, drug abuse & EVs”

Guoku Hu; Kenneth W. Witwer; Vincent C. Bond; Norman Haughey; Fatah Kashanchi; Lynn Pulliam; Shilpa Buch;