publication . Article . 2011

Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice.

Saha, Subhrajit; Bhanja, Payel; Kabarriti, Rafi; Liu, Laibin; Alfieri, Alan A.; Guha, Chandan;
Open Access English
  • Published: 01 Sep 2011 Journal: PLoS ONE, volume 6, issue 9 (issn: 1932-6203, eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
Background Nuclear accidents and terrorism presents a serious threat for mass casualty. While bone-marrow transplantation might mitigate hematopoietic syndrome, currently there are no approved medical countermeasures to alleviate radiation-induced gastrointestinal syndrome (RIGS), resulting from direct cytocidal effects on intestinal stem cells (ISC) and crypt stromal cells. We examined whether bone marrow-derived adherent stromal cell transplantation (BMSCT) could restitute irradiated intestinal stem cells niche and mitigate radiation-induced gastrointestinal syndrome. Methodology/Principal Findings Autologous bone marrow was cultured in mesenchymal basal mediu...
Subjects
free text keywords: Cancer Treatment, Research Article, Biology, Gastroenterology and Hepatology, Medicine, Critical Care and Emergency Medicine, Radiation Exposure, Oncology, Gastrointestinal Cancers, Radiation Biophysics, Q, R, Gastrointestinal Critical Care, Radiation Therapy, Science, Biophysics
Funded by
NIH| Discovery and Target Validation: Proteomics Core
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U19AI091175-01
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1RC2AI087612-01
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
37 references, page 1 of 3

Bhanja, P, Saha, S, Kabarriti, R, Liu, L, Roy-Chowdhury, N. Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice.. PLoS One. 2009; 4: e8014 [OpenAIRE] [PubMed]

Potten, CS, Booth, C, Pritchard, DM. The intestinal epithelial stem cell: the mucosal governor.. Int J Exp Pathol. 1997; 78: 219-243 [OpenAIRE] [PubMed]

Barker, N, van Es, JH, Kuipers, J, Kujala, P, van den Born, M. Identification of stem cells in small intestine and colon by marker gene Lgr5.. Nature. 2007; 449: 1003-1007 [PubMed]

Paris, F, Fuks, Z, Kang, A, Capodieci, P, Juan, G. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.. Science. 2001; 293: 293-297 [PubMed]

Mills, JC, Gordon, JI. The intestinal stem cell niche: there grows the neighborhood.. Proc Natl Acad Sci U S A. 2001; 98: 12334-12336 [OpenAIRE] [PubMed]

Pull, SL, Doherty, JM, Mills, JC, Gordon, JI, Stappenbeck, TS. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury.. Proc Natl Acad Sci U S A. 2005; 102: 99-104 [OpenAIRE] [PubMed]

Brittan, M, Hunt, T, Jeffery, R, Poulsom, R, Forbes, SJ. Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon.. Gut. 2002; 50: 752-757 [OpenAIRE] [PubMed]

Brittan, M, Wright, NA. Gastrointestinal stem cells.. J Pathol. 2002; 197: 492-509 [PubMed]

Riehl, T, Cohn, S, Tessner, T, Schloemann, S, Stenson, WF. Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism.. Gastroenterology. 2000; 118: 1106-1116 [PubMed]

Stenson, WF. Prostaglandins and the epithelial response to radiation injury in the intestine.. Curr Opin Gastroenterol. 2004; 20: 61-64 [PubMed]

Okamoto, R, Yajima, T, Yamazaki, M, Kanai, T, Mukai, M. Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract.. Nat Med. 2002; 8: 1011-1017 [PubMed]

Brittan, M, Chance, V, Elia, G, Poulsom, R, Alison, MR. A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts.. Gastroenterology. 2005; 128: 1984-1995 [PubMed]

Gregory, CA, Prockop, DJ, Spees, JL. Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation.. Exp Cell Res. 2005; 306: 330-335 [PubMed]

Le Blanc, K, Rasmusson, I, Sundberg, B, Gotherstrom, C, Hassan, M. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells.. Lancet. 2004; 363: 1439-1441 [PubMed]

Nemeth, K, Leelahavanichkul, A, Yuen, PS, Mayer, B, Parmelee, A. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production.. Nat Med. 2009; 15: 42-49 [OpenAIRE] [PubMed]

37 references, page 1 of 3
Abstract
Background Nuclear accidents and terrorism presents a serious threat for mass casualty. While bone-marrow transplantation might mitigate hematopoietic syndrome, currently there are no approved medical countermeasures to alleviate radiation-induced gastrointestinal syndrome (RIGS), resulting from direct cytocidal effects on intestinal stem cells (ISC) and crypt stromal cells. We examined whether bone marrow-derived adherent stromal cell transplantation (BMSCT) could restitute irradiated intestinal stem cells niche and mitigate radiation-induced gastrointestinal syndrome. Methodology/Principal Findings Autologous bone marrow was cultured in mesenchymal basal mediu...
Subjects
free text keywords: Cancer Treatment, Research Article, Biology, Gastroenterology and Hepatology, Medicine, Critical Care and Emergency Medicine, Radiation Exposure, Oncology, Gastrointestinal Cancers, Radiation Biophysics, Q, R, Gastrointestinal Critical Care, Radiation Therapy, Science, Biophysics
Funded by
NIH| Discovery and Target Validation: Proteomics Core
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U19AI091175-01
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
,
NIH| Stem Cell Based Therapy For Radiation Induced Gastrointestinal Syndrome
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1RC2AI087612-01
  • Funding stream: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
37 references, page 1 of 3

Bhanja, P, Saha, S, Kabarriti, R, Liu, L, Roy-Chowdhury, N. Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice.. PLoS One. 2009; 4: e8014 [OpenAIRE] [PubMed]

Potten, CS, Booth, C, Pritchard, DM. The intestinal epithelial stem cell: the mucosal governor.. Int J Exp Pathol. 1997; 78: 219-243 [OpenAIRE] [PubMed]

Barker, N, van Es, JH, Kuipers, J, Kujala, P, van den Born, M. Identification of stem cells in small intestine and colon by marker gene Lgr5.. Nature. 2007; 449: 1003-1007 [PubMed]

Paris, F, Fuks, Z, Kang, A, Capodieci, P, Juan, G. Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.. Science. 2001; 293: 293-297 [PubMed]

Mills, JC, Gordon, JI. The intestinal stem cell niche: there grows the neighborhood.. Proc Natl Acad Sci U S A. 2001; 98: 12334-12336 [OpenAIRE] [PubMed]

Pull, SL, Doherty, JM, Mills, JC, Gordon, JI, Stappenbeck, TS. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury.. Proc Natl Acad Sci U S A. 2005; 102: 99-104 [OpenAIRE] [PubMed]

Brittan, M, Hunt, T, Jeffery, R, Poulsom, R, Forbes, SJ. Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon.. Gut. 2002; 50: 752-757 [OpenAIRE] [PubMed]

Brittan, M, Wright, NA. Gastrointestinal stem cells.. J Pathol. 2002; 197: 492-509 [PubMed]

Riehl, T, Cohn, S, Tessner, T, Schloemann, S, Stenson, WF. Lipopolysaccharide is radioprotective in the mouse intestine through a prostaglandin-mediated mechanism.. Gastroenterology. 2000; 118: 1106-1116 [PubMed]

Stenson, WF. Prostaglandins and the epithelial response to radiation injury in the intestine.. Curr Opin Gastroenterol. 2004; 20: 61-64 [PubMed]

Okamoto, R, Yajima, T, Yamazaki, M, Kanai, T, Mukai, M. Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract.. Nat Med. 2002; 8: 1011-1017 [PubMed]

Brittan, M, Chance, V, Elia, G, Poulsom, R, Alison, MR. A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts.. Gastroenterology. 2005; 128: 1984-1995 [PubMed]

Gregory, CA, Prockop, DJ, Spees, JL. Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation.. Exp Cell Res. 2005; 306: 330-335 [PubMed]

Le Blanc, K, Rasmusson, I, Sundberg, B, Gotherstrom, C, Hassan, M. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells.. Lancet. 2004; 363: 1439-1441 [PubMed]

Nemeth, K, Leelahavanichkul, A, Yuen, PS, Mayer, B, Parmelee, A. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production.. Nat Med. 2009; 15: 42-49 [OpenAIRE] [PubMed]

37 references, page 1 of 3
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publication . Article . 2011

Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice.

Saha, Subhrajit; Bhanja, Payel; Kabarriti, Rafi; Liu, Laibin; Alfieri, Alan A.; Guha, Chandan;