Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

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Elks, Cathy E; Perry, John R B; Sulem, Patrick; Chasman, Daniel I; Franceschini, Nora; He, Chunyan; Lunetta, Kathryn L; Visser, Jenny A; Byrne, Enda M; Cousminer, Diana L; Gudbjartsson, Daniel F; Esko, Tõnu; Feenstra, Bjarke; Hottenga, Jouke-Jan; Koller, Daniel L; Kutalik, Zoltán; Lin, Peng; Mangino, Massimo; Marongiu, Mara; McArdle, Patrick F; Smith, Albert V; Stolk, Lisette; van Wingerden, Sophie H; Zhao, Jing Hua; Albrecht, Eva; Corre, Tanguy; Ingelsson, Erik; Hayward, Caroline; Magnusson, Patrik K E; Smith, Erin N; ... view all 175 authors
  • Journal: volume 42,issue 12,pages1,077-85issn: 1061-4036, eissn: 1546-1718
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  • Related identifiers: pmc: PMC3140055, doi: 10.1038/ng.714
  • Subject: Adolescent; Aging/physiology; Body Height/genetics; Body Size/genetics; Child; DNA Copy Number Variations/genetics; Female; Genetic Loci/genetics; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Inheritance Patterns/genetics; Menarche/genetics; Obesity/genetics; Polymorphism, Single Nucleotide/genetics; Quantitative Trait Loci/genetics; Reproducibility of Results; Time Factors ; Colaus Study | Genetics | /dk/atira/pure/subjectarea/asjc/1300/1311 | Article

<p>To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(... View more