Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies

Article, Other literature type English OPEN
Elks, Cathy E ; Perry, John R B ; Sulem, Patrick ; Chasman, Daniel I ; Franceschini, Nora ; He, Chunyan ; Lunetta, Kathryn L ; Visser, Jenny A ; Byrne, Enda M ; Cousminer, Diana L ; Gudbjartsson, Daniel F ; Esko, Tõnu ; Feenstra, Bjarke ; Hottenga, Jouke-Jan ; Koller, Daniel L ; Kutalik, Zoltán ; Lin, Peng ; Mangino, Massimo ; Marongiu, Mara ; McArdle, Patrick F ; Smith, Albert V ; Stolk, Lisette ; van Wingerden, Sophie H ; Zhao, Jing Hua ; Albrecht, Eva ; Corre, Tanguy ; Ingelsson, Erik ; Hayward, Caroline ; Magnusson, Patrik K E ; Smith, Erin N ... view all 51 authors (2010)
  • Publisher: NATURE PUBLISHING GROUP
  • Journal: volume 42, issue 12, pages 1,077-85 (issn: 1061-4036, eissn: 1546-1718)
  • Related identifiers: pmc: PMC3140055, doi: 10.1038/ng.714
  • Subject: Adolescent; Aging/physiology; Body Height/genetics; Body Size/genetics; Child; DNA Copy Number Variations/genetics; Female; Genetic Loci/genetics; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Inheritance Patterns/genetics; Menarche/genetics; Obesity/genetics; Polymorphism, Single Nucleotide/genetics; Quantitative Trait Loci/genetics; Reproducibility of Results; Time Factors ; Colaus Study | Genetics | /dk/atira/pure/subjectarea/asjc/1300/1311 | Article

<p>To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P = 5.4 x 10(-60)) and 9q31.2 (P = 2.2 x 10(... View more