Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

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Lopez, Miguel; Varela, Luis; Vazquez, Maria J.; Rodriguez-Cuenca, Sergio; Gonzalez, Carmen R.; Velagapudi, Vidya R.; Morgan, Donald A.; Schoenmakers, Erik; Agassandian, Khristofor; Lage, Ricardo; Martinez de Morentin, Pablo Blanco; Tovar, Sulay; Nogueiras, Ruben; Carling, David; Lelliott, Christopher; Gallego, Rosalia; Oresic, Matej; Chatterjee, Krishna; Saha, Asish K.; Rahmouni, Kamal; Dieguez, Carlos; Vidal-Puig, Antonio;
(2010)

Thyroid hormones have widespread cellular effects; however it is unclear whether their effects on the central nervous system (CNS) contribute to global energy balance. Here, we demonstrate that either whole body hyperthyroidism or central administration of triiodothyron... View more