Enhancing protein disulfide bond cleavage by UV excitation and electron capture dissociation for top-down mass spectrometry

Article, Other literature type English OPEN

Wongkongkathep, Piriya; Li, Huilin; Zhang, Xing; Ogorzalek Loo, Rachel R.; Julian, Ryan R.; Loo, Joseph A.;

(2015)

Publisher: Elsevier BV

Journal: International Journal of Mass Spectrometry,volume 390,pages137-145 (issn: 1387-3806)

Publisher copyright policies & self-archiving

Related identifiers: pmc: PMC4669582, doi: 10.1016/j.ijms.2015.07.008
Subject: Physical and Theoretical Chemistry | Spectroscopy | Condensed Matter Physics | Instrumentation | Article

The application of ion pre-activation with 266 nm ultraviolet (UV) laser irradiation combined with electron capture dissociation (ECD) is demonstrated to enhance top-down mass spectrometry sequence coverage of disulfide bond containing proteins. UV-based activation can ... View more

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