Enhancing protein disulfide bond cleavage by UV excitation and electron capture dissociation for top-down mass spectrometry

Article, Other literature type English OPEN
Wongkongkathep, Piriya; Li, Huilin; Zhang, Xing; Ogorzalek Loo, Rachel R.; Julian, Ryan R.; Loo, Joseph A.;

The application of ion pre-activation with 266 nm ultraviolet (UV) laser irradiation combined with electron capture dissociation (ECD) is demonstrated to enhance top-down mass spectrometry sequence coverage of disulfide bond containing proteins. UV-based activation can ... View more
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